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Curr Biol August 18, 2014; 24 (16): R746-9.

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation.

Balestra FR , Gönczy P .

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key component of a regulatory complex that activates the transcription of genes required for centriole formation.

PubMed ID: 25137586
Article link: Curr Biol

Species referenced: Xenopus
Genes referenced: mcidas

References :
Ma, Multicilin drives centriole biogenesis via E2f proteins. 2014, Pubmed, Xenbase