Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Dev Growth Differ August 1, 2015; 57 (6): 421-9.
Show Gene links Show Anatomy links

Regeneration inducers in limb regeneration.

Satoh A , Mitogawa K , Makanae A .

Limb regeneration ability, which can be observed in amphibians, has been investigated as a representative phenomenon of organ regeneration. Recently, an alternative experimental system called the accessory limb model was developed to investigate early regulation of amphibian limb regeneration. The accessory limb model contributed to identification of limb regeneration inducers in urodele amphibians. Furthermore, the accessory limb model may be applied to other species to explore universality of regeneration mechanisms. This review aims to connect the insights recently gained to emboss universality of regeneration mechanisms among species. The defined molecules (BMP7 (or2) + FGF2 + FGF8) can transform skin wound healing to organ (limb) regeneration responses. The same molecules can initiate regeneration responses in some species.

PubMed ID: 26100345
Article link: Dev Growth Differ

Species referenced: Xenopus
Genes referenced: bmp7.1 bmp7.2 drg1 fgf2 fgf8 prrx1

Article Images: [+] show captions