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Biochim Biophys Acta February 1, 2015; 1849 (2): 201-9.

COUP-TFs and eye development.

Tang K , Tsai SY , Tsai MJ .

Recent studies reveal that COUP-TF genes are essential for neural development, cardiovascular development, energy metabolism and adipogenesis, as well as for organogenesis of multiple systems. In this review, we mainly describe the COUP-TF genes, molecular mechanisms of COUP-TF action, and their crucial functions in the morphogenesis of the murine eye. Mutations of COUP-TF genes lead to the congenital coloboma and/or optic atrophy in both mouse and human, indicating that the study on COUP-TFs and the eye will benefit our understanding of the etiology of human ocular diseases. This article is part of a Special Issue entitled: Nuclear receptors in animal development.

PubMed ID: 24878540
PMC ID: PMC4246046
Article link: Biochim Biophys Acta
Grant support: [+]

Species referenced: Xenopus
Genes referenced: apoa1 cyp17a1 cyp2d6 e2f1 foxc1 hey2 irx4 nr2f2 nr2f5 nrp1 nrp2 pax6 ppara sox9 tbx5 wnt10b

References [+] :
Al-Kateb, NR2F1 haploinsufficiency is associated with optic atrophy, dysmorphism and global developmental delay. 2013, Pubmed