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J Physiol Sci
2015 Nov 01;656:507-14. doi: 10.1007/s12576-015-0402-7.
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Dicalcin, a zona pellucida protein that regulates fertilization competence of the egg coat in Xenopus laevis.
Miwa N
.
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Fertilization is a highly coordinated process whereby sperm interact with the egg-coating envelope (called the zona pellucida, ZP) in a taxon-restricted manner, Fertilization triggers the resumption of the cell cycle of the egg, ultimately leading to generation of a new organism that contains hereditary information of the parents. The complete sperm-ZP interaction comprises sperm recognition of the ZP, the acrosome reaction, penetration of the ZP, and fusion with the egg. Recent evidence suggests that these processes involve oligosaccharides associated with a ZP constituent (termed ZP protein), the polypeptide backbone of a ZP protein, and/or the proper three-dimensional filamentous structure of the ZP. However, a detailed description of the molecular mechanisms involved in sperm-ZP interaction remains elusive. Recently, I found that dicalcin, a novel ZP protein-associated protein, suppresses fertilization through its association with gp41, the frog counterpart of the mammalian ZPC protein. This review focuses on molecular aspects of sperm-ZP interaction and describes the fertilization-suppressive function of dicalcin and associated molecular mechanisms. The amount of dicalcin in the ZP significantly correlates with alteration of the lectin-staining pattern within the ZP and the orientation pattern of ZP filaments, which may assist in elucidating the complex molecular mechanisms that underlie sperm-ZP interaction.
Baibakov,
Sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosis.
2007, Pubmed
Baibakov,
Sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosis.
2007,
Pubmed
Bailey,
Factors regulating sperm capacitation.
2010,
Pubmed
Blount,
Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli.
1996,
Pubmed
Bounoutas,
Touch sensitivity in Caenorhabditis elegans.
2007,
Pubmed
Chachisvilis,
G protein-coupled receptors sense fluid shear stress in endothelial cells.
2006,
Pubmed
Chiu,
Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding.
2007,
Pubmed
Clark,
A role for carbohydrate recognition in mammalian sperm-egg binding.
2014,
Pubmed
Donato,
Functions of S100 proteins.
2013,
Pubmed
Florman,
O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity.
1985,
Pubmed
Gahlay,
Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein.
2010,
Pubmed
Hao,
Osteopontin reduces polyspermy during in vitro fertilization of porcine oocytes.
2006,
Pubmed
Heizmann,
S100 proteins: structure, functions and pathology.
2002,
Pubmed
Hirohashi,
Egg and sperm recognition systems during fertilization.
2008,
Pubmed
Inoda,
Effect of osmolality on the initiation of sperm motility in Xenopus laevis.
1987,
Pubmed
,
Xenbase
Kimura,
Affinity binding of hamster oviductin to spermatozoa and its influence on in vitro fertilization.
1994,
Pubmed
Kubo,
Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes.
1999,
Pubmed
,
Xenbase
Kung,
A possible unifying principle for mechanosensation.
2005,
Pubmed
Larabell,
The extracellular matrix of Xenopus laevis eggs: a quick-freeze, deep-etch analysis of its modification at fertilization.
1988,
Pubmed
,
Xenbase
Lindsay,
Oviductin, the Xenopus laevis oviductal protease that processes egg envelope glycoprotein gp43, increases sperm binding to envelopes, and is translated as part of an unusual mosaic protein composed of two protease and several CUB domains.
1999,
Pubmed
,
Xenbase
Litscher,
Egg extracellular coat proteins: from fish to mammals.
2007,
Pubmed
Miwa,
Cloning and characterization of Xenopus dicalcin, a novel S100-like calcium-binding protein in Xenopus eggs.
2007,
Pubmed
,
Xenbase
Miwa,
Fertilization competence of the egg-coating envelope is regulated by direct interaction of dicalcin and gp41, the Xenopus laevis ZP3.
2015,
Pubmed
,
Xenbase
Miwa,
Characterization of p26olf, a novel calcium-binding protein in the frog olfactory epithelium.
2000,
Pubmed
Miwa,
Frog p26olf, a molecule with two S100-like regions in a single peptide.
2003,
Pubmed
Miwa,
Purification and molecular cloning of a novel calcium-binding protein, p26olf, in the frog olfactory epithelium.
1998,
Pubmed
Miwa,
Dicalcin inhibits fertilization through its binding to a glycoprotein in the egg envelope in Xenopus laevis.
2010,
Pubmed
,
Xenbase
Miwa,
S100-annexin complexes--biology of conditional association.
2008,
Pubmed
Miwa,
Calcium-binding by p26olf, an S100-like protein in the frog olfactory epithelium.
2001,
Pubmed
Nickel,
The unconventional secretory machinery of fibroblast growth factor 2.
2011,
Pubmed
Olson,
Allurin, a 21-kDa sperm chemoattractant from Xenopus egg jelly, is related to mammalian sperm-binding proteins.
2001,
Pubmed
,
Xenbase
Perez-Aguilar,
G protein-coupled receptors mediate coronary flow- and agonist-induced responses via lectin-oligosaccharide interactions.
2014,
Pubmed
Pries,
The endothelial surface layer.
2000,
Pubmed
Ren,
A sperm ion channel required for sperm motility and male fertility.
2001,
Pubmed
Rubio,
Role of the endothelial glycocalyx in dromotropic, inotropic, and arrythmogenic effects of coronary flow.
2000,
Pubmed
Sachs,
Stretch-activated ion channels: what are they?
2010,
Pubmed
Spargo,
Evolution and nomenclature of the zona pellucida gene family.
2003,
Pubmed
,
Xenbase
Storch,
G protein-mediated stretch reception.
2012,
Pubmed
Suarez,
Sperm transport in the female reproductive tract.
2006,
Pubmed
Talevi,
Heterogeneity of the zona pellucida carbohydrate distribution in human oocytes failing to fertilize in vitro.
1997,
Pubmed
Tanaka,
Molecular modeling of single polypeptide chain of calcium-binding protein p26olf from dimeric S100B(betabeta).
1999,
Pubmed
Tian,
Xenopus laevis sperm receptor gp69/64 glycoprotein is a homolog of the mammalian sperm receptor ZP2.
1999,
Pubmed
,
Xenbase
Töpfer-Petersen,
Glycobiology of fertilization in the pig.
2008,
Pubmed
Uebi,
Comprehensive interaction of dicalcin with annexins in frog olfactory and respiratory cilia.
2007,
Pubmed
,
Xenbase
Ueda,
Characterization of the acrosome reaction-inducing substance in Xenopus (ARISX) secreted from the oviductal pars recta onto the vitelline envelope.
2003,
Pubmed
,
Xenbase
Ueda,
Acrosome reaction in sperm of the frog, Xenopus laevis: its detection and induction by oviductal pars recta secretion.
2002,
Pubmed
,
Xenbase
Visconti,
Ion channels, phosphorylation and mammalian sperm capacitation.
2011,
Pubmed
Wassarman,
A profile of fertilization in mammals.
2001,
Pubmed
Wassarman,
Recent aspects of mammalian fertilization research.
2005,
Pubmed
Yanagimachi,
Fertility of mammalian spermatozoa: its development and relativity.
1994,
Pubmed