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Cell Mol Life Sci
2016 Mar 01;735:1103-16. doi: 10.1007/s00018-015-2041-9.
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MALT1 is not alone after all: identification of novel paracaspases.
Hulpiau P
,
Driege Y
,
Staal J
,
Beyaert R
.
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Paracaspases and metacaspases are two families of caspase-like proteins identified in 2000. Up until now paracaspases were considered a single gene family with one known non-metazoan paracaspase in the slime mold Dictyostelium and a single animal paracaspase called MALT1. Human MALT1 is a critical signaling component in many innate and adaptive immunity pathways that drive inflammation, and when it is overly active, it can also cause certain forms of cancer. Here, we report the identification and functional analysis of two new vertebrate paracaspases, PCASP2 and PCASP3. Functional characterization indicates that both scaffold and protease functions are conserved across the three vertebrate paralogs. This redundancy might explain the loss of two of the paralogs in mammals and one in Xenopus. Several of the vertebrate paracaspases currently have incorrect or ambiguous annotations. We propose to annotate them accordingly as PCASP1, PCASP2, and PCASP3 similar to the caspase gene nomenclature. A comprehensive search in other metazoans and in non-metazoan species identified additional new paracaspases. We also discovered the first animal metacaspase in the sponge Amphimedon. Comparative analysis of the active site suggests that paracaspases constitute one of the several subclasses of metacaspases that have evolved several times independently.
Akagi,
A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
1999, Pubmed
Akagi,
A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
1999,
Pubmed
Alnemri,
Human ICE/CED-3 protease nomenclature.
1996,
Pubmed
Aravind,
Classification of the caspase-hemoglobinase fold: detection of new families and implications for the origin of the eukaryotic separins.
2002,
Pubmed
Asplund-Samuelsson,
Prokaryotic caspase homologs: phylogenetic patterns and functional characteristics reveal considerable diversity.
2012,
Pubmed
Baens,
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.
2014,
Pubmed
Choi,
New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases.
2013,
Pubmed
Coornaert,
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
2008,
Pubmed
Dierlamm,
The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.
1999,
Pubmed
Ferch,
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells.
2009,
Pubmed
Fuentes-Prior,
The protein structures that shape caspase activity, specificity, activation and inhibition.
2004,
Pubmed
Hachmann,
Mechanism and specificity of the human paracaspase MALT1.
2012,
Pubmed
Hailfinger,
Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.
2009,
Pubmed
Hailfinger,
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.
2011,
Pubmed
Hamilton,
T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.
2014,
Pubmed
Jabara,
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.
2013,
Pubmed
Jeltsch,
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
2014,
Pubmed
Jiang,
Genome-wide comparative analysis of metacaspases in unicellular and filamentous cyanobacteria.
2010,
Pubmed
Koonin,
Origin and evolution of eukaryotic apoptosis: the bacterial connection.
2002,
Pubmed
Langel,
Multiple protein domains mediate interaction between Bcl10 and MALT1.
2008,
Pubmed
Mazzone,
Functional characterization of zebrafish (Danio rerio) Bcl10.
2015,
Pubmed
Mc Guire,
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.
2014,
Pubmed
McLuskey,
Crystal structure of a Trypanosoma brucei metacaspase.
2012,
Pubmed
Nakaya,
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.
2014,
Pubmed
Paul,
T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.
2014,
Pubmed
Pelzer,
The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.
2013,
Pubmed
Qiao,
Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.
2013,
Pubmed
Qiu,
Oligomeric structure of the MALT1 tandem Ig-like domains.
2011,
Pubmed
Rast,
Lamprey immunity is far from primitive.
2013,
Pubmed
Rebeaud,
The proteolytic activity of the paracaspase MALT1 is key in T cell activation.
2008,
Pubmed
Ruefli-Brasse,
Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.
2003,
Pubmed
Ruland,
Differential requirement for Malt1 in T and B cell antigen receptor signaling.
2003,
Pubmed
Saheb,
A functional connection of Dictyostelium paracaspase with the contractile vacuole and a possible partner of the vacuolar proton ATPase.
2013,
Pubmed
Scudiero,
The three CARMA sisters: so different, so similar: a portrait of the three CARMA proteins and their involvement in human disorders.
2014,
Pubmed
Sodergren,
The genome of the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
Staal,
A two-step activation mechanism of MALT1 paracaspase.
2012,
Pubmed
Staal,
Regulation of NF-κB signaling by caspases and MALT1 paracaspase.
2011,
Pubmed
Staal,
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.
2011,
Pubmed
Tsiatsiani,
Metacaspases.
2011,
Pubmed
Uehata,
Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.
2013,
Pubmed
Uren,
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.
2000,
Pubmed
Vercammen,
Are metacaspases caspases?
2007,
Pubmed
Vercammen,
Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine.
2004,
Pubmed
Wiesmann,
Structural determinants of MALT1 protease activity.
2012,
Pubmed
Wong,
Crystal structure of the yeast metacaspase Yca1.
2012,
Pubmed
Young,
A new "brew" of MALT1 inhibitors.
2012,
Pubmed
Yu,
Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.
2011,
Pubmed
Yuan,
Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate.
2014,
Pubmed
