Stern AT , Forman SA .

R01 GM089745 NIGMS NIH HHS , GM089745 NIGMS NIH HHS , P41-GM103311 NIGMS NIH HHS , P41 GM103311 NIGMS NIH HHS

Alkire, Consciousness and anesthesia. 2008, Pubmed

Alkire, Consciousness and anesthesia. 2008, Pubmed
Althoff, X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. 2014, Pubmed
Bai, The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. 1999, Pubmed
Bali, Defining the propofol binding site location on the GABAA receptor. 2004, Pubmed , Xenbase
Baumann, Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement. 2002, Pubmed , Xenbase
Bertaccini, Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor. 2013, Pubmed
Bocquet, X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. 2009, Pubmed
Chen, Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. 2012, Pubmed
Chiara, Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue. 2012, Pubmed
Chiara, Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor. 2013, Pubmed
Desai, Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. 2009, Pubmed , Xenbase
Dunne, An N-terminal histidine regulates Zn(2+) inhibition on the murine GABA(A) receptor beta3 subunit. 2002, Pubmed , Xenbase
Eaton, Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. 2015, Pubmed , Xenbase
Franks, Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors. 2015, Pubmed
Goren, Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment. 2004, Pubmed , Xenbase
Hanwell, Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. 2012, Pubmed
Hibbs, Principles of activation and permeation in an anion-selective Cys-loop receptor. 2011, Pubmed
Hilf, Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. 2009, Pubmed
Hosie, Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. 2006, Pubmed
Jayakar, Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. 2014, Pubmed
Jurd, General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. 2003, Pubmed
Karlin, Substituted-cysteine accessibility method. 1998, Pubmed
Krasowski, 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor. 2002, Pubmed , Xenbase
Li, Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors. 2010, Pubmed
Li, Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. 2006, Pubmed
Mascia, Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. 2000, Pubmed , Xenbase
McCracken, A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics. 2010, Pubmed , Xenbase
Mihic, Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. 1997, Pubmed , Xenbase
Miller, Crystal structure of a human GABAA receptor. 2014, Pubmed
Olsen, GABA A receptors: subtypes provide diversity of function and pharmacology. 2009, Pubmed
Parikh, Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility. 2011, Pubmed
Ruesch, An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors. 2012, Pubmed , Xenbase
Rüsch, Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation. 2004, Pubmed , Xenbase
Rüsch, Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors. 2005, Pubmed , Xenbase
Stewart, Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation. 2008, Pubmed , Xenbase
Stewart, Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors. 2013, Pubmed , Xenbase
Stewart, Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics. 2014, Pubmed , Xenbase
Stewart, State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor. 2013, Pubmed , Xenbase
Velisetty, Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC). 2012, Pubmed
Wilkins, Identification of a beta subunit TM2 residue mediating proton modulation of GABA type A receptors. 2002, Pubmed
Wooltorton, Identification of a Zn2+ binding site on the murine GABAA receptor complex: dependence on the second transmembrane domain of beta subunits. 1997, Pubmed , Xenbase
Yip, A propofol binding site on mammalian GABAA receptors identified by photolabeling. 2013, Pubmed
Zeller, Identification of a molecular target mediating the general anesthetic actions of pentobarbital. 2007, Pubmed