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Dev Cell August 24, 2015; 34 (4): 421-34.

Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces.

Scarpa E , Szabó A , Bibonne A , Theveneau E , Parsons M , Mayor R .

Contact inhibition of locomotion (CIL) is the process through which cells move away from each other after cell-cell contact, and it contributes to malignant invasion and developmental migration. Various cell types exhibit CIL, whereas others remain in contact after collision and may form stable junctions. To investigate what determines this differential behavior, we study neural crest cells, a migratory stem cell population whose invasiveness has been likened to cancer metastasis. By comparing pre-migratory and migratory neural crest cells, we show that the switch from E- to N-cadherin during EMT is essential for acquisition of CIL behavior. Loss of E-cadherin leads to repolarization of protrusions, via p120 and Rac1, resulting in a redistribution of forces from intercellular tension to cell-matrix adhesions, which break down the cadherin junction. These data provide insight into the balance of physical forces that contributes to CIL in cells in vivo.

PubMed ID: 26235046
PMC ID: PMC4552721
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: akt1 cdh1 cdh2 ctnnb1 ctnnd1 fas fn1 foxi4.1 gnpda1 itk mapk1 mtor ptk2 pxn rac1 sox10 twist1
Morpholinos: cdh1 MO1 ctnnd1 MO2

Article Images: [+] show captions
References [+] :
ABERCROMBIE, Invasiveness of sarcoma cells. 1955, Pubmed