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XB-ART-51988
Int J Dev Biol January 1, 2016; 60 (1-3): 65-9.

Expressional characterization of mRNA (guanine-7) methyltransferase (rnmt) during early development of Xenopus laevis.

Lokapally A , Metikala S , Hollemann T .


Abstract
Methylation of the guanosine cap structure at the 5'' end of mRNA is essential for efficient translation of all eukaryotic cellular mRNAs, gene expression and cell viability and promotes transcription, splicing, polyadenylation and nuclear export of mRNA. In the current study, we present the spatial expression pattern of the Xenopus laevis rnmt homologue. A high percentage of protein sequence similarity, especially within the methyltransferase domain, as well as an increased expression in the cells of the transcriptionally active stages, suggests a conserved RNA cap methylation function. Spatial expression analysis identified expression domains in the brain, the retina, the lens, the otic vesicles and the branchial arches.

PubMed ID: 27002806
Article link: Int J Dev Biol


Species referenced: Xenopus laevis
Genes referenced: fam210a ldlrad4 mc2r mc5r rnmt


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