Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-52366
Rev Endocr Metab Disord 2016 Dec 01;174:559-569. doi: 10.1007/s11154-016-9380-1.
Show Gene links Show Anatomy links

Thyroid hormone regulation of adult intestinal stem cells: Implications on intestinal development and homeostasis.

Sun G , Roediger J , Shi YB .


???displayArticle.abstract???
Organ-specific adult stem cells are essential for organ homeostasis, tissue repair and regeneration. The formation of such stem cells often takes place during postembryonic development, a period around birth in mammals when plasma thyroid hormone concentration is high. The life-long self-renewal of the intestinal epithelium has made mammalian intestine a valuable model to study the function and regulation and adult stem cells. On the other hand, much less is known about how the adult intestinal stem cells are formed during vertebrate development. Here, we will review some recent progresses on this subject, focusing mainly on the formation of the adult intestine during Xenopus metamorphosis. We will discuss the role of thyroid hormone signaling pathway in the process and potential molecular conservations between amphibians and mammals as well as the implications in organ homeostasis and human diseases.

???displayArticle.pubmedLink??? 27554108
???displayArticle.link??? Rev Endocr Metab Disord



References [+] :
Bagamasbad, A role for basic transcription element-binding protein 1 (BTEB1) in the autoinduction of thyroid hormone receptor beta. 2008, Pubmed, Xenbase