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Int J Dev Biol January 1, 2016; 60 (4-6): 151-7.
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Noggin 1 overexpression in retinal progenitors affects bipolar cell generation.

Messina A , Bridi S , Bozza A , Bozzi Y , Baudet ML , Casarosa S .

Waves of Bone Morphogenetic Proteins (BMPs) and their antagonists are present during initial eye development, but their possible roles in retinogenesis are still unknown. We have recently shown that noggin 1, a BMP antagonist, renders pluripotent cells able to differentiate into retinal precursors, and might be involved in the maintenance of retinal structures in the adult vertebrate eye. Here, we report that noggin 1, differently from noggin 2 and noggin 4, is expressed during all phases of Xenopus laevis retinal development. Gain-of-function experiments by electroporation in the optic vesicle show that overexpression of noggin 1 significantly decreases the number of bipolar cells in the inner nuclear layer of the retina, without significantly affecting the generation of the other retinal cell types. Our data suggest that BMP signaling could be involved in the differentiation of retinal progenitors into specific retinal subtypes during late phases of vertebrate retinal development.

PubMed ID: 27389985
Article link: Int J Dev Biol

Species referenced: Xenopus laevis
Genes referenced: h3-3a nog nog2 nog4 rcvrn.1 rcvrn.2 rho syp
Antibodies: H3f3a Ab9 Nog Ab2 Rcvrn Ab1 Rho Ab10 Rho Ab11 Syp Ab2

Phenotypes: Xla Wt + nog (Fig.4 F)

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