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J Cell Biol March 28, 2016; 212 (7): 803-13.
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Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo.

Melchionda M , Pittman JK , Mayor R , Patel S .

Increasing evidence implicates Ca(2+) in the control of cell migration. However, the underlying mechanisms are incompletely understood. Acidic Ca(2+) stores are fast emerging as signaling centers. But how Ca(2+) is taken up by these organelles in metazoans and the physiological relevance for migration is unclear. Here, we identify a vertebrate Ca(2+)/H(+)exchanger (CAX) as part of a widespread family of homologues in animals. CAX is expressed in neural crest cells and required for their migration in vivo. It localizes to acidic organelles, tempers evoked Ca(2+) signals, and regulates cell-matrix adhesion during migration. Our data provide new molecular insight into how Ca(2+) is handled by acidic organelles and link this to migration, thereby underscoring the role of noncanonical Ca(2+) stores in the control of Ca(2+)-dependent function.

PubMed ID: 27002171
PMC ID: PMC4810305
Article link: J Cell Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: ddx59 twist1 XB5937757 [provisional]
Morpholinos: CAX MO1 CAX MO2

Phenotypes: Xla Wt + CAX MO (Fig 5 a b c d f) [+]

Article Images: [+] show captions
References [+] :
Berridge, Calcium signalling: dynamics, homeostasis and remodelling. 2003, Pubmed