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Genesis January 1, 2017; 55 (1-2):

Targeted integration of genes in Xenopus tropicalis.

Shi Z , Tian D , Xin H , Lian J , Guo X , Chen Y .

With the successful establishment of both targeted gene disruption and integration methods in the true diploid frog Xenopus tropicalis, this excellent vertebrate genetic model now is making a unique contribution to modelling human diseases. Here, we summarize our efforts on establishing homologous recombination-mediated targeted integration in Xenopus tropicalis, the usefulness, and limitation of targeted integration via the homology-independent strategy, and future directions on how to further improve targeted gene integration in Xenopus tropicalis.

PubMed ID: 28095621
Article link: Genesis

Species referenced: Xenopus tropicalis
Genes referenced: ets1 etv2

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