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XB-ART-5320
Dev Genes Evol July 1, 2003; 213 (7): 355-9.

Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis.



Abstract
Dystroglycan is a cell surface receptor involved in the pathogenesis of muscular dystrophy, and plays a critical role in the assembly and homeostasis of basement membranes. Since data about the amphibian homologue are limited, we have cloned the full-length dystroglycan cDNAs from the frog Xenopus laevis. Using in situ hybridization, we show that mRNA expression is dynamic, particularly in the notochord at the end of gastrulation and during neurulation, suggesting that the protein might play unexplored roles in the specification and/or formation of this tissue. Subsequently, the transcripts are detected in the otic vesicle, the developing brain, and in mesenchymal cells of the visceral arches, as well as in pharyngeal endoderm, the pronephros, pronephric ducts, proctodaeum and the somites.

PubMed ID: 12739143
Article link: Dev Genes Evol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: dag1

References [+] :
Cohen, Distribution of alpha-dystroglycan during embryonic nerve-muscle synaptogenesis. 1995, Pubmed, Xenbase