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Cold Spring Harb Perspect Biol July 1, 2015; 7 (7): a015784.

Emergent Properties of the Metaphase Spindle.

A metaphase spindle is a complex structure consisting of microtubules and a myriad of different proteins that modulate microtubule dynamics together with chromatin and kinetochores. A decade ago, a full description of spindle formation and function seemed a lofty goal. Here, we describe how work in the last 10 years combining cataloging of spindle components, the characterization of their biochemical activities using single-molecule techniques, and theory have advanced our knowledge. Taken together, these advances suggest that a full understanding of spindle assembly and function may soon be possible.

PubMed ID: 26134313
PMC ID: PMC4484974
Article link: Cold Spring Harb Perspect Biol

References [+] :
Akhmanova, Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. 2001, Pubmed