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Development June 15, 2016; 143 (12): 2121-34.

Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex.

Martinez-Garay I , Gil-Sanz C , Franco SJ , Espinosa A , Molnár Z , Mueller U .

Cadherins are crucial for the radial migration of excitatory projection neurons into the developing neocortical wall. However, the specific cadherins and the signaling pathways that regulate radial migration are not well understood. Here, we show that cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and α- and β-catenins. Surprisingly, perturbation of cadherin-mediated signaling does not affect the formation and extension of leading processes of migrating neocortical neurons. Instead, movement of the cell body and nucleus (nucleokinesis) is disrupted. This defect is partially rescued by overexpression of LIS1, a microtubule-associated protein that has previously been shown to regulate nucleokinesis. Taken together, our findings indicate that cadherin-mediated signaling to the cytoskeleton is crucial for nucleokinesis of neocortical projection neurons during their radial migration.

PubMed ID: 27151949
PMC ID: PMC4920171
Article link:

Species referenced: Xenopus
Genes referenced: cdh2 cdh4 cdh6 chdh ctnnb1 dcx epha8 npat pafah1b1 pax6 slc7a5 ucp1

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References [+] :
Abe, EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. 2008, Pubmed