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J Cardiovasc Dev Dis June 4, 2016; 3 (2):

A Matter of the Heart: The African Clawed Frog Xenopus as a Model for Studying Vertebrate Cardiogenesis and Congenital Heart Defects.

Hempel A , Kühl M .

The African clawed frog, Xenopus, is a valuable non-mammalian model organism to investigate vertebrate heart development and to explore the underlying molecular mechanisms of human congenital heart defects (CHDs). In this review, we outline the similarities between Xenopus and mammalian cardiogenesis, and provide an overview of well-studied cardiac genes in Xenopus, which have been associated with congenital heart conditions. Additionally, we highlight advantages of modeling candidate genes derived from genome wide association studies (GWAS) in Xenopus and discuss commonly used techniques.

PubMed ID: 29367567
PMC ID: PMC5715680
Article link: J Cardiovasc Dev Dis

Genes referenced: frzb2

Article Images: [+] show captions
References [+] :
Abu-Issa, Heart field: from mesoderm to heart tube. 2007, Pubmed