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MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2.
Chen H
,
Liu L
,
Li X
,
Shi Y
,
Liu N
.
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MicroRNA-1294 (miR-1294) has been reported to be involved in the progression of esophageal squamous cell carcinoma. However, the function and the mechanisms of miR-1294 in glioma remain unclear. In this study, we explore the potential biological roles of miR-1294 in glioma cell lines. First, we detected the aberrant down-regulation of miR-1294 in glioma tissues and cell lines. Second, we determined that miR-1294 suppresses the proliferation, migration and invasiveness and enhances the chemosensitivity of glioma cells lines to temozolomide. Third, we found that the targeting protein for Xenopus kinesin-like protein 2 (TPX2) is the functional target of miR-1294; miR-1294 acts through TPX2 to exert an important biological effect in glioma. Importantly, TPX2 knockdown had the same effect on glioma cell lines as miR-1294 overexpression. In addition, when TPX2 was up-regulated in these cells, the effects of miR-1294 on glioma cell lines were suppressed. Moreover, the effect of miR-1294 on glioma was verified using a xenograft model. These findings demonstrated that miR-1294 inhibits the development of glioma by targeting TPX2. These findings provide a new potential therapeutic target for glioma treatment.
Chang,
miR-145 targets the SOX11 3'UTR to suppress endometrial cancer growth.
2017, Pubmed
Chang,
miR-145 targets the SOX11 3'UTR to suppress endometrial cancer growth.
2017,
Pubmed
Chen,
MicroRNA‑216b inhibits cell proliferation and invasion in glioma by directly targeting metadherin.
2017,
Pubmed
Fu,
TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.
2015,
Pubmed
,
Xenbase
Gu,
TPX2 promotes glioma cell proliferation and invasion via activation of the AKT signaling pathway.
2016,
Pubmed
,
Xenbase
Hsu,
Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability.
2017,
Pubmed
Li,
miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas.
2017,
Pubmed
Li,
MicroRNA-613 impedes the proliferation and invasion of glioma cells by targeting cyclin-dependent kinase 14.
2018,
Pubmed
Liu,
MiR-421 inhibits the malignant phenotype in glioma by directly targeting MEF2D.
2017,
Pubmed
Liu,
MicroRNA-454 inhibits non‑small cell lung cancer cells growth and metastasis via targeting signal transducer and activator of transcription-3.
2018,
Pubmed
Lu,
MiRNA-107 enhances chemosensitivity to paclitaxel by targeting antiapoptotic factor Bcl-w in non small cell lung cancer.
2017,
Pubmed
Luan,
miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.
2018,
Pubmed
Ludwig,
Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer.
2017,
Pubmed
Lv,
miR-137 inhibits melanoma cell proliferation through downregulation of GLO1.
2018,
Pubmed
Pan,
Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer.
2017,
Pubmed
Stamato,
Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma.
2017,
Pubmed
Tomii,
TPX2 expression is associated with poor survival in gastric cancer.
2017,
Pubmed
,
Xenbase
Wang,
MicroRNA-936 induces cell cycle arrest and inhibits glioma cell proliferation by targeting CKS1.
2017,
Pubmed
Wang,
MiR-21 enhanced glioma cells resistance to carmustine via decreasing Spry2 expression.
2017,
Pubmed
Wei,
TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer.
2013,
Pubmed
Wu,
microRNA-204 modulates chemosensitivity and apoptosis of prostate cancer cells by targeting zinc-finger E-box-binding homeobox 1 (ZEB1).
2017,
Pubmed
Xu,
LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma.
2018,
Pubmed
Xu,
MicroRNA-1179 inhibits glioblastoma cell proliferation and cell cycle progression via directly targeting E2F transcription factor 5.
2017,
Pubmed
Yan,
TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
2018,
Pubmed
,
Xenbase
Yang,
Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
2017,
Pubmed
,
Xenbase
Yang,
Expression of miR-149-3p inhibits proliferation, migration, and invasion of bladder cancer by targeting S100A4.
2017,
Pubmed
Zhang,
MiR-381 inhibits migration and invasion in human gastric carcinoma through downregulatedting SOX4.
2017,
Pubmed
Zhou,
MicroRNA-141-3p promotes glioma cell growth and temozolomide resistance by directly targeting p53.
2017,
Pubmed
