Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Environ Sci Pollut Res Int
2020 Feb 01;274:3697-3705. doi: 10.1007/s11356-019-04596-2.
Show Gene links
Show Anatomy links
Effects of glyphosate and a commercial formulation Roundup® exposures on maturation of Xenopus laevis oocytes.
Slaby S
,
Titran P
,
Marchand G
,
Hanotel J
,
Lescuyer A
,
Leprêtre A
,
Bodart JF
,
Marin M
,
Lemiere S
.
???displayArticle.abstract???
Pesticides are often found at high concentrations in small ponds near agricultural field where amphibians are used to live and reproduce. Even if there are many studies on the impacts of phytopharmaceutical active ingredients in amphibian toxicology, only a few are interested in the earlier steps of their life cycle. While their populations are highly threatened with extinction. The aim of this work is to characterize the effects of glyphosate and its commercial formulation Roundup® GT Max on the Xenopus laevis oocyte maturation which is an essential preparation for the laying and the fertilization. Glyphosate is an extensively used herbicide, not only known for its effectiveness but also for its indirect impacts on non-target organisms. Our results showed that exposures to both forms of glyphosate delayed this hormone-dependent process and were responsible for spontaneous maturation. Severe and particular morphogenesis abnormalities of the meiotic spindle were also observed. The MAPK pathway and the MPF did not seem to be affected by exposures. The xenopus oocyte is particularly affected by the exposures and appears as a relevant model for assessing the effects of environmental contamination.
Akcha,
Genotoxicity of diuron and glyphosate in oyster spermatozoa and embryos.
2012, Pubmed
Akcha,
Genotoxicity of diuron and glyphosate in oyster spermatozoa and embryos.
2012,
Pubmed
Bonfanti,
A glyphosate micro-emulsion formulation displays teratogenicity in Xenopus laevis.
2018,
Pubmed
,
Xenbase
Botta,
Transfer of glyphosate and its degradate AMPA to surface waters through urban sewerage systems.
2009,
Pubmed
Brachet,
A cytochemical and ultrastructural analysis of in vitro maturation in amphibian oocytes.
1970,
Pubmed
Duke,
Glyphosate: a once-in-a-century herbicide.
2008,
Pubmed
Dumont,
Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.
1972,
Pubmed
,
Xenbase
Ferrell,
Xenopus oocyte maturation: new lessons from a good egg.
1999,
Pubmed
,
Xenbase
Frödin,
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.
1999,
Pubmed
,
Xenbase
Gelaude,
Nitric oxide donor s-nitroso-n-acetyl penicillamine (SNAP) alters meiotic spindle morphogenesis in Xenopus oocytes.
2015,
Pubmed
,
Xenbase
Guilherme,
European eel (Anguilla anguilla) genotoxic and pro-oxidant responses following short-term exposure to Roundup--a glyphosate-based herbicide.
2010,
Pubmed
Hans,
Histone H3 phosphorylation and cell division.
2001,
Pubmed
Hendzel,
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation.
1997,
Pubmed
Howe,
Toxicity of glyphosate-based pesticides to four North American frog species.
2004,
Pubmed
Ji,
Atrazine and malathion shorten the maturation process of Xenopus laevis oocytes and have an adverse effect on early embryo development.
2016,
Pubmed
,
Xenbase
Lajmanovich,
Toxicity of four herbicide formulations with glyphosate on Rhinella arenarum (anura: bufonidae) tadpoles: B-esterases and glutathione S-transferase inhibitors.
2011,
Pubmed
Lopes,
Effect of glyphosate on the sperm quality of zebrafish Danio rerio.
2014,
Pubmed
Marin,
Xenopus laevis oocyte maturation is affected by metal chlorides.
2015,
Pubmed
,
Xenbase
Martinez,
Impacts of glyphosate-based herbicides on disease resistance and health of crops: a review.
2018,
Pubmed
Mesnage,
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
2015,
Pubmed
Monastersky,
Biodiversity: Life--a status report.
2014,
Pubmed
Moore,
Relative toxicity of the components of the original formulation of Roundup to five North American anurans.
2012,
Pubmed
Peruzzo,
Levels of glyphosate in surface waters, sediments and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina.
2008,
Pubmed
Rissoli,
Effects of glyphosate and the glyphosate based herbicides Roundup Original(®) and Roundup Transorb(®) on respiratory morphophysiology of bullfrog tadpoles.
2016,
Pubmed
Slaby,
Maturation of Xenopus laevis oocytes under cadmium and lead exposures: Cell biology investigations.
2017,
Pubmed
,
Xenbase
Stebbins-Boaz,
Oocyte maturation in Xenopus laevis is blocked by the hormonal herbicide, 2,4-dichlorophenoxy acetic acid.
2004,
Pubmed
,
Xenbase
Struger,
Occurrence of glyphosate in surface waters of Southern Ontario.
2008,
Pubmed
Van Hooser,
Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation.
1998,
Pubmed
Yadav,
Toxic and genotoxic effects of Roundup on tadpoles of the Indian skittering frog (Euflictis cyanophlyctis) in the presence and absence of predator stress.
2013,
Pubmed