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Sci Rep January 1, 2019; 9 (1): 5025.
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Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS.

Kim E , Jeong I , Chung AY , Kim S , Kwon SH , Seong JY , Park HC .

Spexin (SPX) is a highly conserved neuropeptide that is widely expressed in mammalian brain and peripheral tissue. In teleost, SPX1 is mainly expressed in the brain and ovary, and is involved in reproduction and food intake. A second form of SPX, SPX2, was recently identified in chick, Xenopus, and zebrafish. The expression pattern and roles of SPX2 are unknown. SPX (spx1) is highly expressed in the vertebrate brain, but its distribution, circuits, and interactions with its putative receptor are unknown. Here, we observed expression of spx1 in the midbrain and hindbrain, and spx2 in the hypothalamic preoptic area using in situ RNA hybridization in zebrafish. Analysis of transgenic reporter zebrafish revealed that hindbrain SPX1 neurons are PAX2+ inhibitory interneurons and project to the spinal cord, where they interact with galanin receptor 2b (GALR2b) neurons, suggesting that hindbrain SPX1 neurons are reticulospinal neurons. spx1 mRNA and SPX1 reporter expression were observed in dorsal habenula (dHb). SPX1 neurons in the dHb project to the interpeduncular nucleus (IPN), where GALR2a and GALR2b expression was also observed, suggesting that habenula SPX1 neurons may interact with GALR2a/2b in the IPN.

PubMed ID: 30903017
PMC ID: PMC6430828
Article link: Sci Rep
Grant support: [+]

Species referenced: Xenopus
Genes referenced: agrp gal.1 galr2 galr3 lgals4.2 pax2 pomc sf3b4 slc6a5 spx1

Article Images: [+] show captions
References [+] :
Agetsuma, The habenula is crucial for experience-dependent modification of fear responses in zebrafish. 2010, Pubmed