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XB-ART-56037
Dev Biol 2018 Dec 01;444 Suppl 1:S36-S46. doi: 10.1016/j.ydbio.2018.05.018.
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The neural border: Induction, specification and maturation of the territory that generates neural crest cells.

Pla P , Monsoro-Burq AH .


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The neural crest is induced at the edge between the neural plate and the nonneural ectoderm, in an area called the neural (plate) border, during gastrulation and neurulation. In recent years, many studies have explored how this domain is patterned, and how the neural crest is induced within this territory, that also participates to the prospective dorsal neural tube, the dorsalmost nonneural ectoderm, as well as placode derivatives in the anterior area. This review highlights the tissue interactions, the cell-cell signaling and the molecular mechanisms involved in this dynamic spatiotemporal patterning, resulting in the induction of the premigratory neural crest. Collectively, these studies allow building a complex neural border and early neural crest gene regulatory network, mostly composed by transcriptional regulations but also, more recently, including novel signaling interactions.

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Species referenced: Xenopus laevis
Genes referenced: anos1 ap2a1 apoc1 arl6ip1 bambi bmp4 cdh1 cdh11 cdh2 cdh6 chd7 dll1 dlx3 dlx5 dnmt3a ednra eno1 ets1 fgf3 fgf4 fgf8 foxd3 gata2 gbx2 grn hes4 id3 irx1 itk kdm4a krt12.4 meis3 msx1 msx2 myb myc nkx6-3 notch1 nsd3 pax3 pax7 pdgfra pfkfb4 prdm1 prdm12 rhov six1 snai1 snai2 snw1 sox10 sox11 sox2 sox5 sox8 sox9 tfap2a tfap2e twist1 wnt1 zic1 zic5 znf703


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