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Front Cell Dev Biol January 1, 2017; 5 59.

Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?

Gentzel M , Schambony A .

Dishevelled (DVL) proteins are highly conserved in the animal kingdom and are important key players in β-Catenin-dependent and -independent Wnt signaling pathways. Vertebrate genomes typically comprise three DVL genes, DVL1, DVL2, and DVL3. Expression patterns and developmental functions of the three vertebrate DVL proteins however, are only partially redundant in any given species. Moreover, expression and function of DVL isoforms have diverged between different vertebrate species. All DVL proteins share basic functionality in Wnt signal transduction. Additional, paralog-specific interactions and functions combined with context-dependent availability of DVL isoforms may play a central role in defining Wnt signaling specificity and add selectivity toward distinct downstream pathways. In this review, we recapitulate briefly cellular functions of DVL paralogs, their role in vertebrate embryonic development and congenital disease.

PubMed ID: 28603713
PMC ID: PMC5445114
Article link: Front Cell Dev Biol

Species referenced: Xenopus
Genes referenced: celsr1 ctnnb1 dvl1 dvl2 dvl3 fzd6 pitx2 ror2 vangl2 wnt1 wnt11 wnt5a

Disease Ontology terms: autosomal dominant Robinow syndrome 1

Article Images: [+] show captions
References [+] :
Afzal, Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. 2000, Pubmed