Aquat Toxicol 2019 Sep 01;214:105237. doi: 10.1016/j.aquatox.2019.105237.

Effects of cis-bifenthrin enantiomers on the growth, behavioral, biomarkers of oxidative damage and bioaccumulation in Xenopus laevis.

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Chirality should be taken into consideration when assessing the effect of synthetic pyrethroids to aquatic environmental safety. In our study, 96 h acute toxicity assay showed that enantiomers of cis-BF had an addictive effect of toxicity on Xenopus laevis and R-cis-bifenthrin(R-cis-BF) had higher acute toxicity than S-cis-BF. In chronic assay, R-cis-BF exerted more toxic effect on behavior and development of tadpoles than S-cis-BF, and there was also enantioselective effect of cis-BF on antioxidant enzyme and LDH activity. Besides, thyroid development was also affected at the gene and hormone level, with varied effects observed with different exposure enantiomers. Moreover, in the enantioselective accumulation and tissue distribution of enantiomer assays, results showed that R-cis-BF had higher affinity to organisms than S-cis-BF. This study provided the evidence that chiral pesticides enantioselectively affected development of amphibians, and also shed light on the understanding of enantioselectivity in both acute and chronic eco-toxicities to improve risk assessment and regulation of chiral pesticides.

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Species referenced: Xenopus laevis
Genes referenced: dio2 rpl8 thrb trh tshb
GO keywords: larval behavior