Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-56603
Adv Exp Med Biol 2019 Jan 01;1185:401-405. doi: 10.1007/978-3-030-27378-1_66.
Show Gene links Show Anatomy links

Autophagy Induction by HDAC Inhibitors Is Unlikely to be the Mechanism of Efficacy in Prevention of Retinal Degeneration Caused by P23H Rhodopsin.

Wen RH , Loewen AD , Vent-Schmidt RYJ , Moritz OL .


???displayArticle.abstract???
We previously found that valproic acid (VPA) and other histone deacetylase inhibitors (HDACis) ameliorate retinal degeneration (RD) caused by P23H rhodopsin in Xenopus laevis larvae and hypothesized that this may be due to enhancement of autophagy. Here we use X. laevis expressing an autophagy marker to assess effects of HDACis on autophagy. We also assess the effects of non-HDACi activators and inducers of autophagy on RD caused by P23H rhodopsin.

???displayArticle.pubmedLink??? 31884645
???displayArticle.link??? Adv Exp Med Biol


Species referenced: Xenopus laevis
Genes referenced: hdac3 rho