Honjo Y , Ichinohe T .

#15K09453 and #26293277 to T.I., #18K116440 to Y.H Ministry of Education, Culture, Sports, Science and Technology

Adams, Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. 2010, Pubmed

Adams, Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. 2010, Pubmed
Adiga, Delayed and stage specific phosphorylation of H2AX during preimplantation development of gamma-irradiated mouse embryos. 2007, Pubmed
Aizawa, The medaka midblastula transition as revealed by the expression of the paternal genome. 2003, Pubmed
Aizawa, Identification of radiation-sensitive mutants in the Medaka, Oryzias latipes. 2004, Pubmed
Aladjem, ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. 1998, Pubmed
Amodeo, Histone titration against the genome sets the DNA-to-cytoplasm threshold for the Xenopus midblastula transition. 2015, Pubmed , Xenbase
Anderson, Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus. 1997, Pubmed , Xenbase
Artus, Cell cycle regulation during early mouse embryogenesis. 2008, Pubmed
Bartek, Chk1 and Chk2 kinases in checkpoint control and cancer. 2003, Pubmed
Brown, ATR disruption leads to chromosomal fragmentation and early embryonic lethality. 2000, Pubmed
Brugarolas, Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. 1999, Pubmed
Conn, The DNA damage checkpoint in embryonic cell cycles is dependent on the DNA-to-cytoplasmic ratio. 2004, Pubmed , Xenbase
De Santis, Radiation effects on development. 2007, Pubmed
Domon, Cell cycle-dependent radiosensitivity in two-cell mouse embryos in culture. 1980, Pubmed
Domon, Radiosensitivity variation during the cell cycle in pronuclear mouse embryos in vitro. 1982, Pubmed
Dumon-Jones, Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. 2003, Pubmed
Elson, Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. 1996, Pubmed
Fan, Homologous recombination in zebrafish ES cells. 2006, Pubmed
Filion, Survival responses of human embryonic stem cells to DNA damage. 2009, Pubmed
Fung, Repair at single targeted DNA double-strand breaks in pluripotent and differentiated human cells. 2011, Pubmed
Gartel, p21--negative regulator of the cell cycle. 1996, Pubmed
Georgakilas, Induction and repair of clustered DNA lesions: what do we know so far? 2013, Pubmed
Giachino, Maintenance of genomic stability in mouse embryonic stem cells: relevance in aging and disease. 2013, Pubmed
Goodhead, Weiss Lecture. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. 1993, Pubmed
Gu, The embryonic and fetal effects in ICR mice irradiated in the various stages of the preimplantation period. 1997, Pubmed
HULSE, THE EFFECTS OF IONISING RADIATION ON THE EMBRYO AND FOETUS: A REVIEW OF EXPERIMENTAL DATA. 1964, Pubmed
Hagmann, Homologous recombination and DNA-end joining reactions in zygotes and early embryos of zebrafish (Danio rerio) and Drosophila melanogaster. 1998, Pubmed , Xenbase
Hamilton, A comparison of the x-ray sensitivity of haploid and diploid zygotes of Xenopus laevis. 1967, Pubmed , Xenbase
He, p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. 2016, Pubmed
Hensey, A developmental timer that regulates apoptosis at the onset of gastrulation. 1997, Pubmed , Xenbase
Heyer, Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development. 2000, Pubmed
Hidaka, Cell lines derived from a medaka radiation-sensitive mutant have defects in DNA double-strand break responses. 2010, Pubmed
Hirao, DNA damage-induced activation of p53 by the checkpoint kinase Chk2. 2000, Pubmed
Hong, Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. 2004, Pubmed
Honjo, Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. 2019, Pubmed
Hyodo-Taguchi, Change in dose-survival time relationship after x-irradiation during embryonic development in the fish, Oryzias latipes. 1969, Pubmed
Hyodo-Taguchi, RBE of fast neutrons for inhibition of hatchability in fish embryos irradiated at different developmental stages. 1973, Pubmed
Ijiri, X-ray effect on the development of Xenopus laevis embryos--with special reference to primordial germ cells. 1979, Pubmed , Xenbase
Ikegami, Effect of inhibitors of DNA replication on early zebrafish embryos: evidence for coordinate activation of multiple intrinsic cell-cycle checkpoints at the mid-blastula transition. 1997, Pubmed
Ikegami, Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo. 1999, Pubmed , Xenbase
Jacquet, Embryonic death, dwarfism and fetal malformations after irradiation of embryos at the zygote stage: studies on two mouse strains. 1995, Pubmed
Kienzler, DNA repair activity in fish and interest in ecotoxicology: a review. 2013, Pubmed
Kraeussling, Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos. 2011, Pubmed
Kumagai, The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. 1998, Pubmed , Xenbase
Lange, Cdks and cyclins link G1 length and differentiation of embryonic, neural and hematopoietic stem cells. 2010, Pubmed
Lindeman, Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon. 2019, Pubmed
Liu, Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. 2000, Pubmed
Lossaint, Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. 2011, Pubmed
Luo, Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. 1999, Pubmed
Matsuda, Preliminary study on chromosomal aberrations in eggs of mice fertilized in vitro after X-irradiation. 1983, Pubmed
McAleer, Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers. 2005, Pubmed
Miyachi, Marked depression of time interval between fertilization period and hatching period following exposure to low-dose X-rays in zebrafish. 2003, Pubmed
Momcilovic, DNA damage responses in human induced pluripotent stem cells and embryonic stem cells. 2010, Pubmed
Momcilović, Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells. 2009, Pubmed
Müller, Lethal and teratogenic effects after exposure to X-rays at various times of early murine gestation. 1990, Pubmed
Nagaria, DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity. 2013, Pubmed
Negron, Activation of apoptosis and caspase-3 in zebrafish early gastrulae. 2004, Pubmed
Orford, Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. 2008, Pubmed
Pawlik, Role of cell cycle in mediating sensitivity to radiotherapy. 2004, Pubmed
Peng, DNA damage signaling in early Xenopus embryos. 2008, Pubmed , Xenbase
Peng, Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos. 2007, Pubmed , Xenbase
Peng, Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. 1997, Pubmed
RUSSELL, An analysis of the changing radiation response of the developing mouse embryo. 1954, Pubmed
Roos, Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair. 2007, Pubmed
Roque, Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo. 2012, Pubmed
Rugh, Sequelae of the LD/50 x-ray exposure of the pre-implantation mouse embryo: days 0.0 to 5.0. 1966, Pubmed
Russell, Radiation-sensitivity differences within cell-division cycles during mouse cleavage. 1966, Pubmed
Saretzki, Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. 2004, Pubmed
Serrano, Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells. 2011, Pubmed
Shimada, Effect of heat on radiosensitivity at different developmental stages of embryos of the fish Oryzias latipes. 1985, Pubmed
Sinclair, X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. 1966, Pubmed
Singh, The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. 2009, Pubmed
Solozobova, Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage. 2009, Pubmed
Streffer, Malformations after radiation exposure of preimplantation stages. 1996, Pubmed
Streffer, Biological effects after prenatal irradiation (embryo and fetus). A report of the International Commission on Radiological Protection. 2003, Pubmed
Sussman, DNA repair capacity of zebrafish. 2007, Pubmed
Suvorova, G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. 2016, Pubmed
Takai, Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. 2002, Pubmed
Takai, Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. 2000, Pubmed
Tichy, Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells. 2011, Pubmed
Tichy, Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks. 2010, Pubmed
Van Sloun, The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage. 1999, Pubmed
Wang, Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. 1997, Pubmed
Ward, Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. 1981, Pubmed
Weissenborn, Analysis of structural and numerical chromosomal anomalies at the first, second, and third mitosis after irradiation of one-cell mouse embryos with X-rays or neutrons. 1988, Pubmed
Weissenborn, The one-cell mouse embryo: cell cycle-dependent radiosensitivity and development of chromosomal anomalies in postradiation cell cycles. 1988, Pubmed
Yang, Prenatal irradiation-induced brain neuropathology and cognitive impairment. 2017, Pubmed
Yukawa, Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos. 2007, Pubmed