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XB-ART-57062
F1000Res January 1, 2019; 8
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APC/C: current understanding and future perspectives.

Yamano H .


Abstract
The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle. The APC/C and cyclin-dependent kinase 1 (Cdk1) are just two of the many significant cell cycle regulators and exert control through ubiquitylation and phosphorylation, respectively. The temporal and spatial regulation of the APC/C is achieved by multiple mechanisms, including phosphorylation, interaction with the structurally related co-activators Cdc20 and Cdh1, loading of distinct E2 ubiquitin-conjugating enzymes, binding with inhibitors and differential affinities for various substrates. Since the discovery of APC/C 25 years ago, intensive studies have uncovered many aspects of APC/C regulation, but we are still far from a full understanding of this important cellular machinery. Recent high-resolution cryogenic electron microscopy analysis and reconstitution of the APC/C have greatly advanced our understanding of molecular mechanisms underpinning the enzymatic properties of APC/C. In this review, we will examine the historical background and current understanding of APC/C regulation.

PubMed ID: 31164978
PMC ID: PMC6534075
Article link: F1000Res
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cdc20 cdh1 cdk1 fbxo5 mcc slc25a24 tpr ube2s


Article Images: [+] show captions
References [+] :
Alfieri, Molecular basis of APC/C regulation by the spindle assembly checkpoint. 2016, Pubmed