XB-ART-57069Curr Biol January 1, 2020; 30 (11): R637-R639.
Cell Biology: Tubulin Contributes to Spindle Size Scaling.
Sizes of intracellular structures are important for function, yet mechanisms underlying subcellular size control are largely unexplored. A new study reveals how differences in tubulin populations between two related Xenopus frog species influence microtubule dynamics and spindle length.
PubMed ID: 32516610
Article link: Curr Biol
Species referenced: Xenopus laevis
Genes referenced: kif2a tpx2
Article Images: [+] show captions
|Figure 1. Tubulin amount and source influence spindle size. X. laevis frogs and spindles (red) are larger than X. tropicalis frogs and spindles (blue). X. laevis tubulin (red) is distinct from X. tropicalis tubulin (blue), in part due to a difference in phosphorylation. X. tropicalis spindles grow larger when supplemented with X. tropicalis tubulin, but even larger when X. laevis tubulin is added, giving rise to a spindle (purple) that approximates X. laevis spindle size. (Created with BioRender.com.)|