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J Cell Sci January 1, 2019; 132 (11):

DnaJB6 is a RanGTP-regulated protein required for microtubule organization during mitosis.

Rosas-Salvans M , Scrofani J , Modol A , Vernos I .

Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins. The minus-end-directed dynein motor complex generates spindle inward forces and plays a major role in spindle pole focusing. The dynactin complex regulates many dynein functions, increasing its processivity and force production. Here, we show that DnaJB6 is a novel RanGTP-regulated protein. It interacts with the dynactin subunit p150Glued (also known as DCTN1) in a RanGTP-dependent manner specifically in M-phase, and promotes spindle pole focusing and dynein force generation. Our data suggest a novel mechanism by which RanGTP regulates dynein activity during M-phase.

PubMed ID: 31064815
PMC ID: PMC6589090
Article link: J Cell Sci

Species referenced: Xenopus laevis
Genes referenced: dnajb6 mbp
GO keywords: microtubule cytoskeleton organization involved in mitosis

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References [+] :
Blangy, Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. 1996, Pubmed, Xenbase