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Dev Comp Immunol January 1, 2021; 114 103840.

Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis.

Pentagna N , Pinheiro da Costa T , Soares Dos Santos Cardoso F , Martins de Almeida F , Blanco Martinez AM , Abreu JG , Levin M , Carneiro K .

In the present work we have focused on the Histone Deacetylase (HDAC) control of myeloid cells behavior during Xenopus tail regeneration. Here we show that myeloid differentiation is crucial to modulate the regenerative ability of Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity inhibition during the first wave of myeloid differentiation disrupted myeloid cells dynamics in the regenerative bud as well the mRNA expression pattern of myeloid markers, such as LURP, MPOX, Spib and mmp7. We also functionally bridge the spatial and temporal dynamics of lipid droplets, the main platform of lipid mediators synthesis in myeloid cells during the inflammatory response, and the regenerative ability of Xenopus tadpoles. In addition, we showed that 15-LOX activity is necessary during tail regeneration. Taken together our results support a role for the epigenetic control of myeloid behavior during tissue and organ regeneration, which may positively impact translational approaches for regenerative medicine.

PubMed ID: 32858087
Article link: Dev Comp Immunol

Species referenced: Xenopus laevis
Genes referenced: hdac3 lox mmp7 mpo slurp1l spib
GO keywords: animal organ regeneration [+]
Morpholinos: spib MO4