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Int J Dev Biol January 1, 2021; 65 (4-5-6): 227-233.

Establishing embryonic territories in the context of Wnt signaling.

Velloso I , Maia LA , Amado NG , Reis AH , He X , Abreu JG .

This review highlights the work that my research group has been developing, together with international collaborators, during the last decade. Since we were able to establish Xenopus laevis experimental model in Brazil we have been focused on understanding early embryonic patterns regarding neural induction and axes establishment. In this context, Wnt pathway appears as a major player and has been much explored by us and other research groups. Here we chose to review three published works that we consider landmarks within the history of our research on the developmental biology field and the neural induction and patterning modern findings. We intend to show how our series of discoveries, when painted together, tells a story that covers crucial developmental windows of early differentiation paths of anterior neural tissue. Being those: 1. Establishing Head organizer in contrast to trunk organizer at early gastrula; 2. deciding between neural ectoderm and epidermis ectoderm at the blastula/gastrula stages, and 3. the gathering of prechordal unique properties at late gastrula/early neurula.

PubMed ID: 32930371
Article link: Int J Dev Biol

Genes referenced: cer1 chrd.1 ctnnb1 dkk1 dvl1 gsc gsk3b kremen1 lhx1 notum otx2 sox2 trabd2a
GO keywords: Wnt signaling pathway

Disease Ontology terms: familial adenomatous polyposis

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