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XB-ART-57452
Int J Mol Sci October 14, 2020; 21 (20):

A Common Kinetic Property of Mutations Linked to Episodic Ataxia Type 1 Studied in the Shaker Kv Channel.

Zhao J , Petitjean D , Haddad GA , Batulan Z , Blunck R .


Abstract
(1) Background: Episodic ataxia type 1 is caused by mutations in the KCNA1 gene encoding for the voltage-gated potassium channel Kv1.1. There have been many mutations in Kv1.1 linked to episodic ataxia reported and typically investigated by themselves or in small groups. The aim of this article is to determine whether we can define a functional parameter common to all Kv1.1 mutants that have been linked to episodic ataxia. (2) Methods: We introduced the disease mutations linked to episodic ataxia in the drosophila analog of Kv1.1, the Shaker Kv channel, and expressed the channels in Xenopus oocytes. Using the cut-open oocyte technique, we characterized the gating and ionic currents. (3) Results: We found that the episodic ataxia mutations variably altered the different gating mechanisms described for Kv channels. The common characteristic was a conductance voltage relationship and inactivation shifted to less polarized potentials. (4) Conclusions: We suggest that a combination of a prolonged action potential and slowed and incomplete inactivation leads to development of ataxia when Kv channels cannot follow or adapt to high firing rates.

PubMed ID: 33066705
PMC ID: PMC7589002
Article link: Int J Mol Sci
Grant support: [+]

Genes referenced: kcna1
GO keywords: voltage-gated potassium channel activity

Disease Ontology terms: episodic ataxia type 1

Article Images: [+] show captions
References [+] :
Adelman, Episodic ataxia results from voltage-dependent potassium channels with altered functions. 1996, Pubmed, Xenbase