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???displayArticle.abstract??? Dishevelled proteins are key players of Wnt signaling pathways. They transduce Wnt signals and perform cellular functions through distinct conserved domains. Due to the presence of multiple paralogs, the abundant accumulation of maternal transcripts, and the activation of distinct Wnt pathways, their regulatory roles during vertebrate early development and the mechanism by which they dictate the pathway specificity have been enigmatic and attracted much attention in the past decades. Extensive studies in different animal models have provided significant insights into the structure-function relationship of conserved Dishevelled domains in Wnt signaling and the implications of Dishevelled isoforms in early developmental processes. Notably, intra- and inter-molecular interactions and Dishevelled dosage may be important in modulating the specificity of Wnt signaling. There are also distinct and redundant functions among Dishevelled isoforms in development and disease, which may result from differential spatiotemporal expression patterns and biochemical properties and post-translational modifications. This review presents the advances and perspectives in understanding Dishevelled-mediated Wnt signaling during gastrulation and neurulation in vertebrate early embryos.
Axelrod,
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
1998, Pubmed,
Xenbase
Axelrod,
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
1998,
Pubmed
,
Xenbase
Belinson,
Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.
2016,
Pubmed
Bellipanni,
Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.
2006,
Pubmed
Boutros,
Dishevelled: at the crossroads of divergent intracellular signaling pathways.
1999,
Pubmed
,
Xenbase
Bunn,
Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome.
2015,
Pubmed
Butler,
Planar cell polarity in development and disease.
2017,
Pubmed
Carron,
Specification of anteroposterior axis by combinatorial signaling during Xenopus development.
2016,
Pubmed
,
Xenbase
Cheng,
Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.
2017,
Pubmed
,
Xenbase
Clevers,
Wnt/β-catenin signaling and disease.
2012,
Pubmed
Danyel,
Autosomal dominant Robinow syndrome associated with a novel DVL3 splice mutation.
2018,
Pubmed
De Marco,
Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.
2013,
Pubmed
Djiane,
Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.
2000,
Pubmed
,
Xenbase
Etheridge,
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
2008,
Pubmed
Fuentes,
The maternal coordinate system: Molecular-genetics of embryonic axis formation and patterning in the zebrafish.
2020,
Pubmed
Gammons,
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.
2016,
Pubmed
Gammons,
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
2016,
Pubmed
Gao,
Dishevelled: The hub of Wnt signaling.
2010,
Pubmed
Gentzel,
Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?
2017,
Pubmed
,
Xenbase
Gentzel,
Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation.
2015,
Pubmed
,
Xenbase
Gray,
Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution.
2009,
Pubmed
,
Xenbase
Green,
The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction.
2014,
Pubmed
Habas,
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
2001,
Pubmed
,
Xenbase
Habas,
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
2003,
Pubmed
,
Xenbase
Hamblet,
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.
2002,
Pubmed
Hanáková,
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
2019,
Pubmed
Harnoš,
Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.
2019,
Pubmed
,
Xenbase
Harrison,
Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins.
2020,
Pubmed
Harvey,
Identification of the zebrafish maternal and paternal transcriptomes.
2013,
Pubmed
Humphries,
From instruction to output: Wnt/PCP signaling in development and cancer.
2018,
Pubmed
Jiang,
Novel Regulation of Wnt Signaling at the Proximal Membrane Level.
2016,
Pubmed
Kan,
Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.
2020,
Pubmed
Keller,
Convergent extension in the amphibian, Xenopus laevis.
2020,
Pubmed
,
Xenbase
Kelly,
Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish.
2000,
Pubmed
Kimmel,
Specification and morphogenesis of the zebrafish larval head skeleton.
2001,
Pubmed
Kishida,
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
1999,
Pubmed
Kratzer,
The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
2020,
Pubmed
,
Xenbase
Lee,
Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways.
2015,
Pubmed
,
Xenbase
Lehoczky,
Rethinking WNT signalling.
2018,
Pubmed
Li,
Direct regulation of siamois by VegT is required for axis formation in Xenopus embryo.
2015,
Pubmed
,
Xenbase
Lijam,
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1.
1997,
Pubmed
Liu,
DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.
2020,
Pubmed
Ma,
Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.
2010,
Pubmed
Ma,
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.
2020,
Pubmed
Marlow,
Setting up for gastrulation in zebrafish.
2020,
Pubmed
Mlodzik,
The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
2016,
Pubmed
Ngo,
Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.
2020,
Pubmed
Niehrs,
The complex world of WNT receptor signalling.
2012,
Pubmed
Paclíková,
The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells.
2017,
Pubmed
Pan,
Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1.
2004,
Pubmed
Park,
Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos.
2005,
Pubmed
,
Xenbase
Qi,
Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.
2017,
Pubmed
,
Xenbase
Rauschenberger,
The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.
2017,
Pubmed
,
Xenbase
Rothbächer,
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.
2000,
Pubmed
,
Xenbase
Seo,
Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis.
2017,
Pubmed
,
Xenbase
Sharma,
Dishevelled: A masterful conductor of complex Wnt signals.
2018,
Pubmed
,
Xenbase
Shimizu,
Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction.
2014,
Pubmed
Sinha,
Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.
2012,
Pubmed
Soares,
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
2005,
Pubmed
Sokol,
Analysis of Dishevelled signalling pathways during Xenopus development.
1996,
Pubmed
,
Xenbase
Sokol,
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
1995,
Pubmed
,
Xenbase
Solnica-Krezel,
Maternal contributions to gastrulation in zebrafish.
2020,
Pubmed
Steinhart,
Wnt signaling in development and tissue homeostasis.
2018,
Pubmed
Stricker,
ROR-Family Receptor Tyrosine Kinases.
2017,
Pubmed
Tada,
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.
2000,
Pubmed
,
Xenbase
Tadjuidje,
The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo.
2011,
Pubmed
,
Xenbase
Tauriello,
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.
2012,
Pubmed
,
Xenbase
Umbhauer,
The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling.
2000,
Pubmed
,
Xenbase
Wallingford,
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity.
2005,
Pubmed
Wallingford,
Neural tube closure requires Dishevelled-dependent convergent extension of the midline.
2002,
Pubmed
,
Xenbase
Wallingford,
Dishevelled controls cell polarity during Xenopus gastrulation.
2000,
Pubmed
,
Xenbase
Wallingford,
Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis.
2001,
Pubmed
,
Xenbase
Wang,
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.
2006,
Pubmed
,
Xenbase
Wang,
Dishevelled C-terminus: prolyl and histidinyl motifs.
2012,
Pubmed
White,
DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome.
2015,
Pubmed
White,
DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.
2016,
Pubmed
Wiese,
Wnt signalling: conquering complexity.
2018,
Pubmed
Wong,
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.
2003,
Pubmed
,
Xenbase
Wong,
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.
2000,
Pubmed
Wynshaw-Boris,
Dishevelled: in vivo roles of a multifunctional gene family during development.
2012,
Pubmed
Xing,
Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements.
2018,
Pubmed
Yan,
Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates.
2018,
Pubmed
,
Xenbase
