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MicroPubl Biol January 5, 2021; 2021

Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis.

Vertebrate embryonic development is regulated by a few families of extracellular signaling molecules. Xenopus laevis embryos offer an excellent system to study the cell-cell communication signals that govern embryonic patterning. In the frog embryos, Wnt/β-catenin plays a pivotal role in regulating embryonic axis development, and modulation of the Wnt pathway is required for proper antero-posterior patterning. Recently, a novel secreted, organizer-specific Wnt inhibitor, Bighead, was identified that acts by downregulating Lrp6 plasma membrane levels. Here, I describe a method to purify biologically active Bighead protein and confirm that Bighead promotes Xenopus head development.

PubMed ID: 33426508
Article link: MicroPubl Biol

Genes referenced: apex2 lrp6 myc

Article Images: [+] show captions
References [+] :
Colozza, Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins. 2021, Pubmed, Xenbase