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MicroPubl Biol February 9, 2021; 2021

Actin polymerization is not required for the fast block to polyspermy in the African clawed frog, Xenopus laevis.

Tembo M , Sauer ML , Wisner BW , Beleny DO , Napolitano MA , Carlson AE .

Fertilization of an egg by multiple sperm presents one of the earliest and most prevalent obstacles to successful reproduction. Eggs employ multiple mechanisms to prevent sperm entry into the nascent zygote. The fast block to polyspermy uses a depolarization to inhibit sperm entry. For some external fertilizers, fertilization and the fast block require actin polymerization. Here we explored whether the fast block to polyspermy in the external fertilizer, Xenopus laevis, requires actin polymerization. Inseminating in the presence of inhibitor cytochalasin B, here we demonstrate that actin polymerization is not required for the fast block to polyspermy in X. laevis.

PubMed ID: 33598639
Article link: MicroPubl Biol
Grant support: [+]

Species referenced: Xenopus laevis
GO keywords: prevention of polyspermy

Phenotypes: Xla Wt + CYTOCHALASIN B (Fig.1 E (middle))

Article Images: [+] show captions
References [+] :
Bianchi, Sperm Meets Egg: The Genetics of Mammalian Fertilization. 2017, Pubmed