Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a).
Kuspiel S
,
Wiemuth D
,
Gründer S
.
???displayArticle.abstract???
Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ligands directly activate ASICs as well. Neuropeptides are attractive candidates for alternative agonists of ASICs, because related ionotropic receptors are directly activated by neuropeptides and because diverse neuropeptides modulate ASICs. Recently, it has been reported that the neuropeptide nocistatin directly activates ASICs, including ASIC1a. Here we show that nocistatin does not directly activate ASIC1a expressed in Xenopus oocytes or CHO cells. Moreover, we show that nocistatin acidifies the bath solution to an extent that can fully explain the previously reported activation by this highly acidic peptide. In summary, we conclude that nocistatin only indirectly activates ASIC1a via acidification of the bath solution.
Askwith,
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
2000, Pubmed,
Xenbase
Askwith,
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
2000,
Pubmed
,
Xenbase
Assmann,
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission.
2014,
Pubmed
,
Xenbase
Babini,
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
2002,
Pubmed
,
Xenbase
Bartoi,
Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.
2014,
Pubmed
,
Xenbase
Bassilana,
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.
1997,
Pubmed
,
Xenbase
Borg,
Mechanism and site of action of big dynorphin on ASIC1a.
2020,
Pubmed
,
Xenbase
Du,
Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.
2014,
Pubmed
Farrag,
Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia.
2017,
Pubmed
González-Inchauspe,
Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse.
2017,
Pubmed
Gründer,
Biophysical properties of acid-sensing ion channels (ASICs).
2015,
Pubmed
Kreple,
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.
2014,
Pubmed
Lingueglia,
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel.
1995,
Pubmed
,
Xenbase
Osmakov,
Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3).
2019,
Pubmed
Reiners,
The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain.
2018,
Pubmed
,
Xenbase
Schmidt,
Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis.
2018,
Pubmed
Sherwood,
Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.
2009,
Pubmed
,
Xenbase
Vyvers,
Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators.
2018,
Pubmed
,
Xenbase
Waldmann,
A proton-gated cation channel involved in acid-sensing.
1997,
Pubmed
,
Xenbase
Waldmann,
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.
1997,
Pubmed
Wemmie,
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.
2003,
Pubmed
Zha,
Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines.
2006,
Pubmed
