Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-5821
Differentiation January 1, 2003; 71 (1): 83-9.
Show Gene links Show Anatomy links

Cyclic expression of esr9 gene in Xenopus presomitic mesoderm.

Li Y , Fenger U , Niehrs C , Pollet N .


Abstract
During somitogenesis, the cycling expression of members of the Notch signalling cascade is involved in a segmentation clock that regulates the periodic budding of somites in chicken, mouse, and zebrafish. In frog, genes with cycling expression in the presomitic mesoderm have not been reported. Here, we describe the expression of Xenopus esr9 and esr10, two new members of the Hairy/Enhancer of split related family of bHLH proteins. We show that they are expressed in a highly dynamic fashion, with their mRNA levels oscillating periodically in the presomitic mesoderm during somitogenesis. This dynamic expression is independent of de novo protein synthesis. Thus, expression of esr9 and esr10 is an indicator of the segmentation clock in the amphibian embryo. This confirms the evolutionary conservation of a molecular pathway involved in vertebrate segmentation clock.

PubMed ID: 12558606
Article link: Differentiation


Species referenced: Xenopus laevis
Genes referenced: clock hes5.5 hes5.6 hes5.7 hey2 mespa notch1 ripply2.1


Article Images: [+] show captions