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XB-ART-58631
Cells January 1, 2021; 10 (8):
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ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR.

Gunkel P , Iino H , Krull S , Cordes VC .


Abstract
The nuclear basket (NB) scaffold, a fibrillar structure anchored to the nuclear pore complex (NPC), is regarded as constructed of polypeptides of the coiled-coil dominated protein TPR to which other proteins can bind without contributing to the NB''s structural integrity. Here we report vertebrate protein ZC3HC1 as a novel inherent constituent of the NB, common at the nuclear envelopes (NE) of proliferating and non-dividing, terminally differentiated cells of different morphogenetic origin. Formerly described as a protein of other functions, we instead present the NB component ZC3HC1 as a protein required for enabling distinct amounts of TPR to occur NB-appended, with such ZC3HC1-dependency applying to about half the total amount of TPR at the NEs of different somatic cell types. Furthermore, pointing to an NB structure more complex than previously anticipated, we discuss how ZC3HC1 and the ZC3HC1-dependent TPR polypeptides could enlarge the NB''s functional repertoire.

PubMed ID: 34440706
Article link: Cells


Species referenced: Xenopus laevis
Genes referenced: ccnb1 cul1 lmnb2 mad1l1 mad2l1 mxd1 nbn nup107 nup153 nup62 nup98 nxf1 psmd6 skp1 tpr zc3hc1
GO keywords: nuclear envelope [+]


Article Images: [+] show captions