Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-6473
Nat Neurosci October 1, 2002; 5 (10): 955-62.

Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway.

Shewan D , Dwivedy A , Anderson R , Holt CE .


Abstract
Retinal axons are led out of the eye by netrin-1, an attractive guidance cue which is secreted at the optic nerve head. In the optic pathway, however, netrin-1 is expressed in areas that exclude retinal axon growth. This suggests that axons may change in their responsiveness to netrin-1 as they advance along the pathway. Indeed, in our ''whole-pathway'' preparation in Xenopus, a gradual change from attraction to repulsion occurred as retinal axons emerged from progressively distal points along the pathway. We also found that axons that were aged in culture without pathway experience underwent a similar change, which correlated with a decline in cyclic AMP (cAMP) and netrin-1 receptor expression. Cyclic AMP elevators and adenosine A2b receptor agonists rejuvenated the behavior of old growth cones, causing them to regain attraction to netrin-1, whereas antagonists caused young growth cones to be repelled. These findings show that netrin-1 responsiveness is developmentally regulated and suggest that intrinsic changes that lower cAMP levels underlie this regulation.

PubMed ID: 12352982
Article link: Nat Neurosci


Species referenced: Xenopus
Genes referenced: ntn1

References :
Cohen-Cory, The double life of netrin. 2002, Pubmed, Xenbase