FEBS Lett 2002 Jul 31;5241-3:199-203. doi: 10.1016/s0014-5793(02)03058-2.

GLUT2 is a high affinity glucosamine transporter.

???displayArticle.abstract???
When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V(max) values that are three- to four-fold lower than for glucose. The K(m)s for glucosamine and glucose of GLUT1 and GLUT4 were similar. In contrast, GLUT2 had a much higher apparent affinity for glucosamine than for glucose (K(m)=0.8+/-0.1 mM vs. approximately 17-20 mM). Glucosamine transport by GLUT2 was confirmed in mammalian cells and, using hepatocytes from control or GLUT2-null mice, HgCl(2)-inhibitable glucosamine uptake by liver was shown to be exclusively through GLUT2. These data have implications for glucosamine effects on impaired glucose metabolism and for structure-function studies of transporter sugar binding sites.

???displayArticle.pubmedLink??? 12135767
???displayArticle.link??? FEBS Lett


Species referenced: Xenopus
Genes referenced: slc2a1 slc2a2 slc2a4