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Mech Dev July 1, 2002; 115 (1-2): 123-6.

Cardiac specific expression of Xenopus Popeye-1.

Hitz MP , Pandur P , Brand T , Kühl M .

Popeye genes code for putative transmembrane proteins that are predominantly expressed in heart and skeletal muscle. Here we report on the isolation and expression of a previously unknown Xenopus member of this family, Xenopus Popeye-1 (Xpop-1). Xpop-1 is 60-65% identical to other vertebrate Pop-1 genes at the protein level. Whole-mount in situ hybridization studies revealed a highly specific expression of Xpop-1 whose transcripts are restricted to the embryonic heart and become enriched in the forming ventricle. Interestingly, unlike other known vertebrate Popeye genes, Xpop-1 is exclusively expressed in cardiac tissue and absent from skeletal muscle.

PubMed ID: 12049775
Article link: Mech Dev

Species referenced: Xenopus laevis
Genes referenced: bves myh4 myh6 nkx2-5 nppa

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