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EMBO J June 3, 2002; 21 (11): 2798-806.

A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.

Charlesworth A , Ridge JA , King LA , MacNicol MC , MacNicol AM .

Progression through vertebrate oocyte maturation requires that pre-existing, maternally derived mRNAs be translated in a strict temporal order. The mechanism that controls the timing of oocyte mRNA translation is unknown. In this study we show that the early translational induction of the mRNA encoding the Mos proto-oncogene is mediated through a novel regulatory element within the 3'' untranslated region of the Mos mRNA. This novel element is responsive to the MAP kinase signaling pathway and is distinct from the late acting, cdc2-responsive, cytoplasmic polyadenylation element. Our findings suggest that the timing of maternal mRNA translation is controlled through signal transduction pathways targeting distinct 3'' UTR mRNA elements.

PubMed ID: 12032092
PMC ID: PMC125381
Article link: EMBO J
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cdk1 mapk1 mos pold1

References [+] :
Abrieu, The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. 1999, Pubmed, Xenbase