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EMBO J
2002 May 01;219:2139-48. doi: 10.1093/emboj/21.9.2139.
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N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses.
Huang YS
,
Jung MY
,
Sarkissian M
,
Richter JD
.
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Activity-dependent local translation of dendritic mRNAs is one process that underlies synaptic plasticity. Here, we demonstrate that several of the factors known to control polyadenylation-induced translation in early vertebrate development [cytoplasmic polyadenylation element-binding protein (CPEB), maskin, poly(A) polymerase, cleavage and polyadenylation specificity factor (CPSF) and Aurora] also reside at synaptic sites of rat hippocampal neurons. The induction of polyadenylation at synapses is mediated by the N-methyl-D-aspartate (NMDA) receptor, which transduces a signal that results in the activation of Aurora kinase. This kinase in turn phosphorylates CPEB, an essential RNA-binding protein, on a critical residue that is necessary for polyadenylation-induced translation. These data demonstrate a remarkable conservation of the regulatory machinery that controls signal-induced mRNA translation, and elucidates an axis connecting the NMDA receptor to localized protein synthesis at synapses.
Aakalu,
Dynamic visualization of local protein synthesis in hippocampal neurons.
2001, Pubmed
Aakalu,
Dynamic visualization of local protein synthesis in hippocampal neurons.
2001,
Pubmed
Allison,
Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules.
2000,
Pubmed
Andrésson,
The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway.
1998,
Pubmed
,
Xenbase
Bagni,
Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes.
2000,
Pubmed
Banker,
Developments in neuronal cell culture.
1988,
Pubmed
Bischoff,
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers.
1998,
Pubmed
Boyle,
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates.
1991,
Pubmed
Carlin,
Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities.
1980,
Pubmed
Casadio,
A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.
1999,
Pubmed
Crino,
Molecular characterization of the dendritic growth cone: regulated mRNA transport and local protein synthesis.
1996,
Pubmed
Dunkley,
A rapid method for isolation of synaptosomes on Percoll gradients.
1986,
Pubmed
Gebauer,
Cloning and characterization of a Xenopus poly(A) polymerase.
1995,
Pubmed
,
Xenbase
Gingras,
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
1999,
Pubmed
Groisman,
CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division.
2000,
Pubmed
,
Xenbase
Hodgman,
CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes.
2001,
Pubmed
,
Xenbase
Huber,
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
2000,
Pubmed
Jefferies,
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.
1997,
Pubmed
Kacharmina,
Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites.
2000,
Pubmed
Kang,
A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity.
1996,
Pubmed
Kennedy,
Signal transduction molecules at the glutamatergic postsynaptic membrane.
1998,
Pubmed
Kiebler,
Purification and characterization of rat hippocampal CA3-dendritic spines associated with mossy fiber terminals.
1999,
Pubmed
Kolodziej,
DCC's function takes shape in the nervous system.
1997,
Pubmed
Li,
Enhancement of neurotransmitter release induced by brain-derived neurotrophic factor in cultured hippocampal neurons.
1998,
Pubmed
Martin,
Local protein synthesis and its role in synapse-specific plasticity.
2000,
Pubmed
Mendez,
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.
2000,
Pubmed
,
Xenbase
Mendez,
Translational control by CPEB: a means to the end.
2001,
Pubmed
,
Xenbase
Mendez,
Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex.
2000,
Pubmed
,
Xenbase
Mendez,
Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction.
2002,
Pubmed
,
Xenbase
Nigg,
Mitotic kinases as regulators of cell division and its checkpoints.
2001,
Pubmed
Ouyang,
Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons.
1999,
Pubmed
Ouyang,
Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus.
1997,
Pubmed
Richter,
Selective translation of mRNAs at synapses.
2002,
Pubmed
Sallés,
Analysis of poly(A) tail lengths by PCR: the PAT assay.
1999,
Pubmed
Scheetz,
NMDA receptor-mediated control of protein synthesis at developing synapses.
2000,
Pubmed
Scheetz,
N-methyl-D-aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: a role for N-methyl-D-aspartate receptors in controlling protein synthesis.
1997,
Pubmed
Schmelzle,
TOR, a central controller of cell growth.
2000,
Pubmed
Stebbins-Boaz,
Maskin is a CPEB-associated factor that transiently interacts with elF-4E.
1999,
Pubmed
,
Xenbase
Steward,
Protein synthesis at synaptic sites on dendrites.
2001,
Pubmed
Tang,
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus.
2002,
Pubmed
Ulfig,
Monoclonal antibodies SMI 311 and SMI 312 as tools to investigate the maturation of nerve cells and axonal patterns in human fetal brain.
1998,
Pubmed
Wells,
A role for the cytoplasmic polyadenylation element in NMDA receptor-regulated mRNA translation in neurons.
2001,
Pubmed
Wu,
CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses.
1998,
Pubmed
,
Xenbase
Yanow,
Biochemical pathways by which serotonin regulates translation in the nervous system of Aplysia.
1998,
Pubmed
