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EMBO Rep
2001 Dec 01;212:1119-24. doi: 10.1093/embo-reports/kve245.
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The protein Mago provides a link between splicing and mRNA localization.
Le Hir H
,
Gatfield D
,
Braun IC
,
Forler D
,
Izaurralde E
.
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The proteins Mago and Y14 are evolutionarily conserved binding partners. Y14 is a component of the exon-exon junction complex (EJC), deposited by the spliceosome upstream of messenger RNA (mRNA) exon-exon junctions. The EJC is implicated in post-splicing events such as mRNA nuclear export and nonsense-mediated mRNA decay. Drosophila Mago is essential for the localization of oskar mRNA to the posterior pole of the oocyte, but the functional role of Mago in other species is unknown. We show that Mago is a bona fide component of the EJC. Like Y14, Mago escorts spliced mRNAs to the cytoplasm, providing a direct functional link between splicing and the downstream process of mRNA localization. Mago/Y14 heterodimers are essential in cultured Drosophila cells. Taken together, these results suggest that, in addition to its specialized function in mRNA localization, Mago plays an essential role in other steps of mRNA metabolism.
Blencowe,
Association of nuclear matrix antigens with exon-containing splicing complexes.
1994, Pubmed
Blencowe,
Association of nuclear matrix antigens with exon-containing splicing complexes.
1994,
Pubmed
Blencowe,
A coactivator of pre-mRNA splicing.
1998,
Pubmed
Conklin,
Cloning and gene expression of a novel human ribonucleoprotein.
2000,
Pubmed
Conti,
Nucleocytoplasmic transport enters the atomic age.
2001,
Pubmed
Herold,
NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila.
2001,
Pubmed
Jansen,
mRNA localization: message on the move.
2001,
Pubmed
Kataoka,
Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm.
2000,
Pubmed
,
Xenbase
Kim,
The Y14 protein communicates to the cytoplasm the position of exon-exon junctions.
2001,
Pubmed
,
Xenbase
Kim,
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.
2001,
Pubmed
Le Hir,
The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
2001,
Pubmed
,
Xenbase
Le Hir,
Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions.
2000,
Pubmed
Le Hir,
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.
2000,
Pubmed
,
Xenbase
Luo,
Splicing is required for rapid and efficient mRNA export in metazoans.
1999,
Pubmed
,
Xenbase
Lykke-Andersen,
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
2001,
Pubmed
Mayeda,
Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing.
1999,
Pubmed
McGarvey,
The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes.
2000,
Pubmed
Micklem,
The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila.
1997,
Pubmed
Mingot,
Importin 13: a novel mediator of nuclear import and export.
2001,
Pubmed
Newmark,
mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila.
1997,
Pubmed
,
Xenbase
Shyu,
The double lives of shuttling mRNA binding proteins.
2000,
Pubmed
Sun,
mRNA surveillance in mammalian cells: the relationship between introns and translation termination.
2000,
Pubmed
Zhao,
The mammalian homologue of mago nashi encodes a serum-inducible protein.
1998,
Pubmed
Zhao,
MAGOH interacts with a novel RNA-binding protein.
2000,
Pubmed
van Eeden,
Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole.
2001,
Pubmed
