Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-8327
Science 2001 Oct 19;2945542:564-7. doi: 10.1126/science.1064344.
Show Gene links Show Anatomy links

Induction of pancreatic differentiation by signals from blood vessels.

Lammert E , Cleaver O , Melton D .


???displayArticle.abstract???
Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.

???displayArticle.pubmedLink??? 11577200
???displayArticle.link??? Science


Species referenced: Xenopus laevis
Genes referenced: ins

References :
Bahary, Development. Endothelium--chicken soup for the endoderm. 2001, Pubmed, Xenbase