Lombardo A and Slack JM (2001), Abdominal B-type Hox gene expression in Xenopus...

XB-ART-8663

Mech Dev 2001 Aug 01;1061-2:191-5. doi: 10.1016/s0925-4773(01)00438-5.

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Abdominal B-type Hox gene expression in Xenopus laevis.

Lombardo A , Slack JM .

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We have studied the expression of the Abdominal B-type Hox genes in Xenopus embryos and tadpoles. The probes used represent all paralog groups and are designated Xhoxa9, Xhoxd9, Xhoxd10, Xhoxa11, Xhoxc12 and Xhoxa13 on the basis of comparison to other vertebrates. Three of these genes are novel while the others have previously been detected but expression patterns were only partially described. We find a typical nested pattern of expression in the main body axis, in both central nervous system and mesoderm. All the genes, except Xhoxc12, are also expressed in the mesenchyme of the large intestine and in the limb buds.

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Species referenced: Xenopus laevis
Genes referenced: hoxa11 hoxa13 hoxa9 hoxc12 hoxd10 hoxd9

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	Fig. 2. Xenopus AbdB-type Hox genes have specific domain of expression along the anteroposterior axis. Black and white arrows indicate the anterior limit of gene expression in the CNS and the paraxial mesoderm, respectively. Black arrowheads indicate anterior limits in the kidney. First column: expression pattern at stage 20 with the exception of U, which is a stage 26 embryo. Second column: stage 32. Third column: stage 39. Fourth column: detail of expression in the tail bud at stage 32. (A–D) Xhoxa9; (E–H) Xhoxd9; (I–L) Xhoxd10; (M–P) Xhoxa11; (Q–V) Xhoxc12; (U–X) Xhoxa13, arrow in W points to the expression in the most distal part of the hindgut.
	Fig. 4. Xenopus AbdB-type Hox gene expression in the developing gut. Expression is confined to the prospective large intestine. It is mesodermal in all cases except Xhoxa13, where it is both endodermal and mesodermal (see insets P′ and T′). pr, proctodeum.
	Fig. 5. Xenopus AbdB-type Hox gene expression in the developing limbs. The anterior of the whole body is to the left. With the limb buds in normal orientation this means that for the buds the anterior is down, posterior is up and dorsal is facing the viewer.

	hoxd9 (homeobox D9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxa13 (homeobox A13) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 26, lateral view, anterior left, dorsal up.
	hoxa13 (homeobox A13) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxa13 (homeobox A13) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, tail region only, lateral view, anterior left, dorsal up.
	hoxa13 (homeobox A13) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 39, tail region only, lateral view, anterior left, dorsal up.
	hoxa9 (homeobox A9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxd9 (homeobox D9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 20, lateral view, anterior left, dorsal up.
	hoxd9 (homeobox D9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxd10 (homeobox D10) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 20, lateral view, anterior left, dorsal up.
	hoxd10 (homeobox D10) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxa11 (homeobox A11) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxc12 (homeobox C12) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 20, lateral view, anterior left, dorsal up.
	hoxc12 (homeobox C12) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 32, lateral view, anterior left, dorsal up.
	hoxa9 (homeobox A9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 51/52, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxa9 (homeobox A9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 55, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxd9 (homeobox D9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 51/52, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxd9 (homeobox D9) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 55, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxd10 (homeobox D10) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 51/52, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxd10 (homeobox D10) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 55, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxa11 (homeobox A11) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 51/52, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxa11 (homeobox A11) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 54, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxa13 (homeobox A13 ) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 51/52, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.
	hoxa13 (homeobox A13) gene expression in Xenopus laevis embryo, assayed via in situ hybridization, NF stage 55, hind limb buds in normal orientation- anterior is down, posterior is up and dorsal is facing viewer.