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XB-ART-9654
Biochem Biophys Res Commun February 9, 2001; 280 (5): 1378-84.

Embryonic XMab21l2 expression is required for gastrulation and subsequent neural development.

Lau GT , Wong OG , Chan PM , Kok KH , Wong RL , Chin KT , Lin MC , Kung HF , Chow KL .


Abstract
Cell fate determining gene mab-21 regulates the proper establishment of neural cell fate and sensory organ identity in nematode. Mammalian homologs of mab-21 have also been implicated to play critical roles in mid-, hindbrain and craniofacial differentiation. We report here the isolation of a mab-21 homolog, XMab21l2, from Xenopus. We showed that its expression in Xenopus was initiated at gastrulation and prominent signal was detected in neurulating embryos at the neural tube, the optic tissue, the developing midbrain, and the pharyngeal pouches. We demonstrated by RNA interference (RNAi), together with other antisense approaches, that XMab21l2 expression is required for the completion of gastrulation and subsequent neural development.

PubMed ID: 11162683
Article link: Biochem Biophys Res Commun


Species referenced: Xenopus
Genes referenced: mab21l2 pax6 tbxt


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