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XB-ANTIBODY-14579962

Antibody Name: Cdh1 Ab2

Common Name: E-cadherin

RRID: AB_528117
Synonyms: 8C2, cd324, cdhe, ecad

Antigens
Gene: cdh1
XAO: ectoderm, epithelial cell

Clone Type: Monoclonal
Source: Developmental Studies Hybridoma Bank

Antibody
Clone Number 8C2
Purification
Isotype IgG1
Host Organism mouse
Xenopus Reactivity tropicalis, laevis
Non-Xenopus Reactivity chicken
Description: Generated by Barry Gumbiner. Supplied by DSHB, Cat# 8C2c Citation: (DSHB Cat# 8c2, RRID:AB_528117). Please email citation to DSHB.
Immunogen
Name E-cadherin
Type polypeptide
Post Translational Modifications None
Source Organism frog
Description Purified E-cadherin extracellular domain (100 kDa trypsin fragment ectodomain) from Xenopus A6 kidney cell line. 8C2 only binds the -(Ca++) conformation of E-cadherin. Blocks epithelial cell-cell adhesion and cell junction formation. Stains ectoderm, all epithelia and regions of cell-cell contact. E-cadherin-specific by immunoblotting and immunoprecipitation.
Sequence
Reported Usage
western blot
immunoprecipitation
immunofluorescence
Publications
First: Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm., J Cell Biol 1989  
Most recent: Interaction between SPARC and tubulin in Xenopus., Cell Tissue Res 2004  
View All Papers