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Results 1 - 50 of 58 results

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Line Name Species Mutated Gene Description Availability
Xtr.wwoxemHorb

X.tropicalis wwox CRISPR knockout of wwox (WW domain containing oxidoreductase), a gene associated with esophageal can... NXR
Xtr.vwa2emNXR

X.tropicalis vwa2 CRISPR knock out of vwa2 (von Willebrand factor A domain containing 2 ). Germ line transmission conf... NXR
Xtr.tupmZimml

X.tropicalis unknown Mutation affecting axial development identified in the Mill Hill screen of ENU-induced mutations. EXRC
Xtr.tp53em_del2/+_Vlemx

X.tropicalis tp53 Deletion is expected to give rise to nonsense-mediated decay since due to the frame-shifting deletio...
Xtr.tp53em_del1/em_del2_Vlemx

X.tropicalis tp53 Two types of F1 tp53 heterozygotes, each with a distinct variant of a deletion (em_del1/+ and em_del...
Xtr.tp53em_del1/+_Vlemx

X.tropicalis tp53 Deletion is expected to give rise to nonsense-mediated decay since due to the frame-shifting deleti...
Xtr.thratmShiyb

X.tropicalis This line was created using TALENS targeting exon 4 (the third coding exon) of the X. tropicalis thr...
Xtr.tbxtemJcsm

X.tropicalis tbxt Talen-induced 2bp deletion in exon 1 of tbxt (T-box transcription factor T) gene. Mutation destroys ... EXRC
Xtr.tbxt.2em2Jcsm

X.tropicalis tbxt.2 Talen-induced mutant line. Talen-induced 7-bp deletion in third exon of T, brachyury homolog, gene ... EXRC
Xtr.tbxt.2em1Jcsm

X.tropicalis tbxt.2 Talen-mediated mutant line. Talen-induced 7-bp deletion in third exon of T, brachyury homolog, gene ... EXRC
Xtr.tbxt,tbxt.2emJcsm

X.tropicalis tbxt Double talen-induced mutant line. Talen induced 2-bp deletion in exon 1 of tbxt and 7 bp deletion in... EXRC
Xtr.srd5a2emNXR

X.tropicalis srd5a2 CRISPR knockout of srd5a2 (steroid 5 alpha-reductase 2), Confirmed germ line transmission. animals c... NXR
Xtr.sox3emHorb

X.tropicalis sox3 CRISPR knockout of sox3 (SRY-box 3), Current mosaic founders, Not tested for germline transmission. ... NXR
Xtr.snai1emNXR

X.tropicalis snai1 CRISPR knockout of snai1 (snail family zinc finger 1) in X. tropicalis. germline transmission confir... NXR
Xtr.smad4.1mZimml

X.tropicalis smad4 Mutation affecting haematopoiesis identified in a screen for ENU-induced mutations at Mill Hill. Pos... EXRC
Xtr.six1em2NXR

X.tropicalis six1 CRISPR knockout of six1 (SIX homeobox 1), a gene associated with branchiootorenal syndrome and branc...
Xtr.six1em1NXR

X.tropicalis six1 CRISPR knockout of six1 (SIX homeobox 1), a gene associated with branchiootorenal syndrome and branc... NXR
Xtr.rflciiemNXR

X.tropicalis rflcii CRISPR KO of rflcii ( relaxin family locus C type II ) in X tropicalis. Germ line transmission not y... NXR
Xtr.raxmGrngr

X.tropicalis rax This mutant line was generated in an ENU screen from the Grainger lab by TILLING (Targeting Induced ... NXR
Xtr.pou3f4emHorb

X.tropicalis pou3f4 CRISPR knockout of pou3f4 (POU class 3 homeobox 4). Current mosaic founders, not tested for germline... NXR
Xtr.olig4emHorb

X.tropicalis olig4 CRISPR knockout of olig4 (oligodendrocyte transcription factor 4). Current mosaic founders, not test... NXR
Xtr.nr2f2emNXR

X.tropicalis nr2f2 CRISPR knockout fo nr2f2 (nuclear receptor subfamily 2 group F member 2 ). Germ line transmission co... NXR
Xtr.npntinsZimml

X.tropicalis npnt Nephronectin insertional mutation (probably null). Insertion of Tg(nkx2.5:GFP) transgene between 3rd... EXRC
Xtr.myf6emNXR

X.tropicalis myf6 TALENS knockout of myf6 (myogenic factor 6) in X tropicalis. Germ line transmission not yet confirme... NXR
Xtr.legmZimml

X.tropicalis unknown Mutation affecting otoconia formation identified in the Mill Hill screen of ENU-induced mutations. EXRC
Xtr.kiff11emHorb

X.tropicalis kif11 CRISPR knockout of kif11 (kinesin family member 11). Germ line transmission not yet confirmed. F0 fo... NXR
Xtr.gfi1em2Horb

X.tropicalis gfi1 CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor). Germ line transmissio... NXR
Xtr.gfi1em1Horb

X.tropicalis gfi1 CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor). Germ line transmissio... NXR
Xtr.frzb,frzb2emHorb

X.tropicalis frzb2 double CRISPR knockout of frzb (frizzled related protein ) and frzb2 (frizzled related protein 2). C... NXR
Xtr.fibinemHorb

X.tropicalis fibin CRISPR knockout of fibin (fin bud initiation factor homolog), Confirmed germline transmission. Custo... NXR
Xtr.ezh2emHorb

X.tropicalis ezh2 CRISPR knockout of ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), Germ line trans... NXR
Xtr.eya1em1NXR

X.tropicalis eya1 CRISPR knockout of eya1 (EYA transcriptional coactivator and phosphatase 1). Germline transmission ... NXR
Xtr.dtlemHorb

X.tropicalis dtl CRISPR knockout of dtl (denticleless E3 ubiquitin protein ligase homolog), Current mosaic founders, ... NXR
Xtr.dstmZimml

X.tropicalis unknown Mutation affecting the haematopoietic system identified in the Mill Hill screen for ENU-induced muta... EXRC
Xtr.csnk1g2emNXR

X.tropicalis csnk1g2 CRISPR knockout of csnk1g2 (casein kinase 1 gamma 2). Germ line transmission confirmed. Mutation is ... NXR
Xtr.cacna1hem1NXR

X.tropicalis cacna1h CRISPR knockout of cacna1h (calcium channel, voltage-dependent, T type, alpha 1H subunit). Mutation ... NXR
Xtr.amhem3NXR

X.tropicalis amh CRISPR knockout of amh (anti-Mullerian hormone ). Confirmed germline transmission. Custom mutant gen... NXR
Xtr.amhem1NXR

X.tropicalis amh CRISPR knockout of amh (anti-Mullerian hormone). Germline transmission confirmed. +8bp mutation in a... NXR
Xtr.amhr2emNXR

X.tropicalis amhr2 CRISPR knockout of amhr2 (anti-Mullerian hormone receptor type II ). Confirmed germline transmission... NXR
Xtr.aif1lem1Horb

X.tropicalis aif1l CRISPR knockout of aif1l (allograft inflammatory factor 1-like). Confirmed germline transmission. Cu... NXR
Xtr.ahrem1NXR

X.tropicalis ahr TALEN generated mutant line, made by the NXR. Germ line transmission confirmed. ,+2bp mutation: CCAT... NXR
Xla.xdm-wemNXR

X.laevis xdm-w.L CRISPR knock out of xdm-w (doublesex and mab3 related transcription factor W ). Germ Line transmissi... NXR
Xla.thrbem1NXR

X.laevis thrb.L CRISPR knockout of thrb.L thyroid hormone receptor, beta L homolog). germline transmission confirmed... NXR
Xla.sox10emHorb

X.laevis sox10.L CRISPR knockout of sox10 (SRY-box 10). Confirmed germline transmission in sox10.L (waiting for confi... NXR
Xla.slc45a2em2NXR

X.laevis slc45a2.L CRISPR knockout of slc45a2 (solute carrier family 45 member 2 ). Screened for germline transmission.... NXR
Xla.pkhd1emHorb

X.laevis pkhd1.L CRISPR knockout of pkhd1 (PKHD1, fibrocystin/polyductin), Germ line transmission confirmed. Animals ... NXR
Xla.pkd2emHorb

X.laevis pkd2.L CRISPR knockout of pkd2 (polycystin 2, transient receptor potential cation channel ). Confirmed germ... NXR
Xla.pcntemHorb

X.laevis pcnt.L CRISPR knockout of pcnt (pericentrin ). Confirmed germline transmission. Custom mutant generated by ... NXR
Xla.olig2emHorb

X.laevis olig2.L CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. laevis. KOs both oli... NXR
Xla.npffr1.1emEXRC

X.laevis npffr1.1.L Crispr-Cas9 mutation in the npffr1.1 gene (neuropeptide FF receptor 1, gene 1 ). EXRC

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