Summary Attributions Transgene

Line Name: Xtr.npntinsZimml

Line Images [+] show captions [-] hide captions Xtr.npnt{insZimml} froglets which carry a transgenic insertion (nkx2-5:GFP) in the npnt gene. It was the first insertional mutation to be cloned in Xenopus. Homozyogote Xtr.npnt mutant froglets lack forelimbs, as seen in this skeletal preparation.

Summary
Synonym:	xdm, xenopus de milo, T388, Xtr.Tg(nkx2.5:GFP)
Species:	Xenopus tropicalis
Background Strain:	Unknown
Paternal Line:
Maternal Line:
Color Morph:	pigmented
Phenotype Description:	Homozygous mutants fail to form forelimb buds and all subsequent forelimb structures. Hindlimb development and all other tissues seem to form normally. Cardiac fluorescence due to GFP.
Breeding Type:	OUTBRED
Description:	Nephronectin insertional mutation (probably null). Insertion of Tg(nkx2.5:GFP) transgene between 3rd and 4th exon of npnt gene causing mRNA truncation.
Lab of Origin:	Zimmerman Lab
Line Type:	Mutant, Transgenic
Mutated Gene:	npnt
MTA Required:	No
Public:	Yes
Catalogue Number:

Vendor	RRID	Availability
NXR (US):		No
EXRC (Europe):	EXRC_6008	Yes, order
NBRP (Japan):		No
XLRRI (US):		No
CRB (Europe):		No