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XB-LINE-1695
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Line Name: Xtr.tp53em_del1/em_del2_Vlemx
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| Summary | |
|---|---|
| Synonym: | tp53168stop |
| Species: | Xtr.Nigeria |
| Background Strain: | Xtr.Outbred |
| Paternal Line: | |
| Maternal Line: | |
| Description: | Two types of F1 tp53 heterozygotes, each with a distinct variant of a deletion (em_del1/+ and em_del2/+). Both of these deletions are expected to give rise to nonsense-mediated decay since due to the frame-shifting deletion, the premRNA contains a premature stop codon (tp53168STOP). These heterozygous mutants (F1) were subsequently intercrossed to obtain F2 homozygous mutant animals. |
| Phenotype Description: | |
| Color Morph: | pigmented |
| Breeding Type: | UNKNOWN |
| Lab of Origin: | Vleminckx |
| Line Type: | Mutant |
| Mutated Gene(s): | tp53 |
| MTA Required: | No |
| Public: | Yes |
| Catalogue Number: |
| Stock Center | RRID | Generation | Availability | Mutant Details |
|---|---|---|---|---|
| NXR (US) | ||||
| EXRC (Europe) | ||||
| NBRP (Japan) | ||||
| XLRRI (US) | ||||
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