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Two adjacent phosphorylation sites in the C-terminus of the channel's α-subunit have opposing effects on epithelial sodium channel (ENaC) activity. , Diakov A., Pflugers Arch. July 1, 2022; 474 (7): 681-697.
WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mitogen-activated protein kinase-dependent pathway. , Yue P., Biochim Biophys Acta. October 1, 2013; 1833 (10): 2101-10.
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone- SGK1- Nedd4-2 pathway. , Arroyo JP., J Am Soc Nephrol. September 1, 2011; 22 (9): 1707-19.
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. , Rozansky DJ., J Clin Invest. September 1, 2009; 119 (9): 2601-12.
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. , Edinger RS., J Biol Chem. January 2, 2009; 284 (1): 150-157.
Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation. , Fakitsas P., J Am Soc Nephrol. April 1, 2007; 18 (4): 1084-92.
Renal Ca2+ handling in sgk1 knockout mice. , Sandulache D., Pflugers Arch. July 1, 2006; 452 (4): 444-52.
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase ( Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. , Rauh R., Pflugers Arch. June 1, 2006; 452 (3): 290-9.
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells. , Flores SY., J Am Soc Nephrol. August 1, 2005; 16 (8): 2279-87.
Nedd4-2 isoforms differentially associate with ENaC and regulate its activity. , Itani OA., Am J Physiol Renal Physiol. August 1, 2005; 289 (2): F334-46.
Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells. , Alvarez de la Rosa D., J Gen Physiol. October 1, 2004; 124 (4): 395-407.
SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes. , Zecevic M., Pflugers Arch. April 1, 2004; 448 (1): 29-35.
Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. , Náray-Fejes-Tóth A., Mol Cell Endocrinol. March 31, 2004; 217 (1-2): 197-202.
Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. , Yoo D., J Biol Chem. June 20, 2003; 278 (25): 23066-75.
Short-term aldosterone action on Na, K-ATPase surface expression: role of aldosterone-induced SGK1? , Verrey F., Ann N Y Acad Sci. April 1, 2003; 986 554-61.
SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells. , Verrey F., Cell Physiol Biochem. January 1, 2003; 13 (1): 21-8.
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. , Yun CC., J Am Soc Nephrol. December 1, 2002; 13 (12): 2823-30.
Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase ( Sgk1) in Xenopus Oocytes. , Vuagniaux G., J Gen Physiol. August 1, 2002; 120 (2): 191-201.
Hypotonic induction of SGK1 and Na+ transport in A6 cells. , Rozansky DJ., Am J Physiol Renal Physiol. July 1, 2002; 283 (1): F105-13.
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. , Loffing J., Am J Physiol Renal Physiol. April 1, 2001; 280 (4): F675-82.
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. , Wang J ., Am J Physiol Renal Physiol. February 1, 2001; 280 (2): F303-13.
The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel. , Náray-Fejes-Tóth A., Kidney Int. April 1, 2000; 57 (4): 1290-4.
Role of SGK in mineralocorticoid-regulated sodium transport. , Pearce D., Kidney Int. April 1, 2000; 57 (4): 1283-9.
sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels. , Náray-Fejes-Tóth A., J Biol Chem. June 11, 1999; 274 (24): 16973-8.
Epithelial sodium channel regulated by aldosterone-induced protein sgk. , Chen SY., Proc Natl Acad Sci U S A. March 2, 1999; 96 (5): 2514-9.